Antiseizure drugs drug interactions with

Clobazam is not available in the USA but is marketed in most countries and is widely used in a variety of seizure types. It is a 1,5-benzodiazepine (other marketed benzodiazepines are 1,4-benzodiazepines) and reportedly has less sedative potential than benzodiazepines marketed in the USA. Whether the drug has significant clinical advantages is not clear. It has a half-life of 18 hours and is effective at dosages of 0.5-1 mg/kg/d. It does interact with some other antiseizure drugs and causes adverse effects typical of the benzodiazepines efficacy, in some patients, is limited by the development of tolerance. 

Gabapentin is absorbed after oral administration and is not metabolized in humans. It is not bound to plasma proteins. It is excreted unchanged, mainly in the urine. Its half-life, when it is used as monotherapy, is 4 to 6 hours. It has no known interactions with other antiseizure drugs. 

Interactions of Antiseizure Drugs with Hepatic Microsomal Enzymes ... 

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