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Potential herb-drug interactions

Pharmacogenetics in Potential Herb-Drug Interactions Effects of Ginseng on CYP3A4 and CYP2C9 Allelic Variants... [Pg.59]

Table 2 Reported and potential herb-drug interactions... Table 2 Reported and potential herb-drug interactions...
Kupiec T, Raj V. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J Anal Toxicol... [Pg.794]

This herbal product has the most data available to support its usefulness as an antidepressant. Nevertheless, only minimal information is available about its pharmacology and its relative risk-benefit ratio. At least seven different biologically active chemicals have been isolated from crude extracts of hypericum. Several are ubiquitous in the plant kingdom. The exceptions are hypericin and pseudohypericin, which have been assumed to be responsible for any antidepressant activity of this product. Nevertheless, there is the potential for one or more of these seven compounds and their metabolites to mediate desired or undesired effects, particularly when used in combination with other medications (i.e., herb-drug interactions). [Pg.129]

Herbal medicines are becoming more and more popular, and indeed some herbal products may be considered to benefit people with liver disease, e.g. Silybum marianum (milk thistle), Picrorhiza kurroa, Phyllanthus, etc. Herbal hepatotoxicity is increasingly being recognised, for example, with kava kava, black cohosh, and many traditional Chinese remedies. The range of liver injury includes minor transaminase elevations, acute and chronic hepatitis, steatosis, cholestasis, zonal or diffuse hepatic necrosis, veno-occlusive disease and acute liver failure. In addition to the potential for hepatotoxicity, herb-drug interactions may affect the safety and efficacy of concurrent medical therapy [15]. [Pg.142]

Following reports about the potential for herb-drug interactions, many national regulatory agencies issued warnings about the use of St. John s wort and its safety was reviewed (21,22). [Pg.843]

Ernst E. Herb-drug interactions potentially important but woefully under-researched. Eur J Clin Pharmacol 2000 56(8) 523. ... [Pg.1623]

Appreciation is also due to Joseph Betz, Ph.D. and the late Mary Frances Picciano, Ph.D. of the Office of Dietary Supplements (ODS) at the National Institutes of Health. Dr. Betz shared his ideas on the makeup of the Expert Advisory Council and on the importance of addressing the potential for an herb to modify the effect of a drug taken concomitantly, commonly referred to as an herb-drug interaction (a topic that was outside of the scope of the first edition). Dr. Picciano facilitated ODS s significant financial support of the revision process and ensured that the planned revision met high academic and scientific standards. [Pg.1010]


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