Lithium drug interactions with

Nonsteroidal antiinflammatory drugs, interaction with lithium, 36 66 No-phonon transition, 35 324 Norbomadiene complexes with cobalt, 12 286 with copper, 12 328, 330, 331 with gold, 12 348, 349 with group VIB metals, 12 231 with group VnB metals, 12 241 with iron, 12 265 with palladium, 12 314 with platinum, 12 319 with rhodium, 12 300-302 with ruthenium, 12 278, 279 with silver, 12 340-342, 344, 346 Norbomylsiloxane, 42 226, 228 Notch receptor proteins, 46 473, 475 h (N)" oxime complexes, osmium, 37 260 h (N,0) oxime complexes, osmium, 37 260 (NPr ljiFeCfrdto),], magnetization versus temperature, 43 230... 

There are several clinically significant drug interactions with lithium, including the following ... 

Belmaker, R. H. How does lithium work in manic depression Clinical and psychological correlates of the inositol theory. Ann. Rev. Med. 47 (1996) 47-60. Finley, P. R. Clinical relevance of drug interactions with lithium. Clin. 

Drug interactions with lithium have been reviewed (569-573) another review focused on interactions in the elderly (573). A review of drug interactions with lithium considered both pharmacokinetic interactions [for example diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs)] and pharmacodynamic interactions (for example antipsychotic drugs, SSRIs) and summarized the most important ones in tabular form (569). 

Muller-Oerlinghausen B. Drug interactions with lithium. A guide for clinicians. CNS Drugs 1999 11 41-8. 

Finley PR, Warner MD, Peabody CA. Clinical relevance of drug interactions with lithium. Clin Pharmacokinet 1995 29(3) 172-91. 

Drug Interactions with Lithium Lithium and the Thyroid Gland Lithium and Bone Microbiological Effects of Lithium Conclusion References... 

Toxic effects of lithium can be fatal. Early signs of lithium toxicity are vomiting and severe diarrhoea followed by tremor, ataxia, renal impairment and convulsions. Many non-steroidal anti-inflammatory drugs interact with lithium to increase its plasma... 

Which best describes the mechanism of interaction of nonsteroidal anti-inflammatory drugs (NSAlDs) with lithium salts ... 

Dubovsky SL, Franks RD, Allen S. Verapamil a new antimanic drug with potential interactions with lithium. J Clin Psychiatry 1987 48 371-372. 

Two reviews of drug interactions with antibiotics briefly and incompletely discussed lithium (611,612). 

A review of drug interactions with analgesics in the dental literature concluded that NSAIDs should be used briefly, if at all, in patients taking lithium, especially in the... 

Interactions. Several types of drug interfere with lithium excretion by the renal tubules, causing the plasma concentration to rise. These include diuretics (thiazides more than loop type), ACE inhibitors and angiotensin-11 antagonists, and nonsteroidal anti-inflammatory analgesics. Theophylline and sodium-containing antacids reduce plasma lithium concentration. The effects can be important because lithium has such a low therapeutic ratio. Diltiazem, verapamil, carbamazepine and pheny-toin may cause neurotoxicity without affecting the plasma lithium. Concomitant use of thioridazine should be avoided as ventricular arrhythmias may result. 

The authors attribute the bradycardia to an interaction with lithium as the low dose of propranolol was considered unlikely to cause bradycardia alone. They also point out that both drugs affect the movement of calcium across cell membranes, which could account for the decreased contraction rate of the heart muscle, and thus bradycardia in this patient. They suggest careful monitoring in elderly patients with atherosclerotic cardiovascular problems. ... 

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