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Diazepam interactions with other drugs

Admixture incompatibility- Do not mix or dilute with other solutions or drugs in syringe or infusion flask. Diazepam interacts with plastic containers and administration sets, significantly decreasing availability of drug delivered. [Pg.1219]

With the important exception of additive effects when combined with other CNS depressants, including alcohol, BZDs interact with very few drugs. Disulfiram (see the section The Alcoholic Patient in Chapter 14) and cimetidine may increase BZD blood levels, and diazepam may increase blood levels of digoxin and phenytoin. Antacids may reduce the clinical effects of clorazepate by hindering its biotransformation to desmethyidiazepam. Coadministration of a BZD and another drug known to induce seizures may possibly increase seizure risk, especially if the BZD is abruptly withdrawn. Furthermore, as noted earlier, important interactions have been reported among nefazodone, erythromycin, troleandomycin, and other macrolide antibiotics, as well as itraconazole. In each case, metabolism is inhibited, and triazolam levels can increase significantly. [Pg.242]

V. Drug or laboratory interactions. There is some evidence that milk thistle may inhibit CYP2C9 and CYP3A4 enzyme activity, which might theoretically increase plasma levels of dmgs metabolized by these enzymes, including amitriptyline, diazepam, clozapine, warfarin, mirtazapine, ketoconazole, and others. Drug interactions with milk thistle extract have not been reported in humans. [Pg.501]

Established interactions. These increases in bioavailability might be expected to increase the extent of the sedation and amnesia due to these benzodiazepines, but in young healthy adults this is apparently of little importance. The clinical effects of the interaction with diazepam appear not to have been investigated. The effects of midazolam and triazolam may be more enhanced than those of other benzodiazepines, because these drugs are more dependent on CYP3A4 for their metabolism (see Mechanism, abovej.What is not clear is whether other factors such as old age or liver cirrhosis might increase the risk of adverse effects with concurrent use. [Pg.727]

The documentation of these interactions is limited but what has been reported is consistent with the way rifampicin interacts with many other drugs. The clinical importance of some of these interactions between the benzodiazepines and related drugs and rifampicin has not yet been assessed but what is known suggests that the dosage of diazepam and nitrazepam may need to be increased if rifampicin is given. Be alert for a reduction in the effects of other similarly metabolised benzodiazepines (e.g. chlordiazepoxide, flurazepam). [Pg.736]

A mentally retarded patient had occasional hypothermic episodes (below 35°C) while taking lithium and diazepam, but not while taking either drug alone. After taking lithium 1 g and diazepam 30 mg daily for 17 days, the patient s temperature fell from 35.4 to 32°C over 2 hours, and he became comatose with reduced reflexes, dilafed pupils, a systolic blood pressure of 40 to 60 mmHg, a pulse rate of 40 and no piloerecfor response. The reasons for fhis reacfion are nof known. This is an isolated case and fhere-fore concurrenf use need nof be avoided, buf be alert for any evidence of hypothermia. There seems to be no evidence of this adverse interaction with any of the other benzodiazepines. [Pg.1120]


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See also in sourсe #XX -- [ Pg.204 ]




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Diazepam drug interactions

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