Cephalosporins interaction with other drugs

Although the manufacturers of ceftazidime issue a caution about the use of high doses of cephalosporins with other nephrotoxic drugs, they say that clinical experience has not shown this to be a problem with ceftazidime at the recommended doses.The rest of the information about other cephalosporins and furosemide is fairly sparse. Most appear not to interact adversely, with a few possible exceptions, namely cefalotin (nephrotoxicity in a single case and animal studies ) and cefacetrile (nephrotoxicity in animal studies ). Care is clearly prudent with these two cephalosporins. 

The increased levels and decreased renal excretion of clinafloxacin caused by probenecid are not considered large enough to warrant dosage adjustment," and most of the changes seen with the other quinolones were of a similar magnitude. However, caution has been advised in the presence of other drugs that may also compete for renal excretion (such as some penicillins or cephalosporins). " Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact. 

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