Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Drug-induced autoimmune disease autoimmunity

Drug-induced autoimmune diseases, autoimmune-like disorders, and hypersensitivity reactions are a major concern and have caused the withdrawal of drugs from the market or restriction of their use. [Pg.219]

Evaluate other possible causes space-occupying lesion (which may or may not be malignant), drug-induced CNS disease, autoimmune disease, and trauma.8,9... [Pg.1037]

Drugs can cause a wide variety of other autoimmune reactions. One example is myasthenia gravis, which is characterized by muscle weakness and is mediated by antibodies against the acetylcholine receptor at the neuromuscular junction. It has been reported in association with penicillamine [66], gold salts [67], and procainamide [68]. Another form of drug-induced autoimmunity is polymyositis, which is an autoimmune disease... [Pg.459]

The mechanisms of autoimmunity may also entail interaction with MHC structures determined by the HLA alleles. Individuals carrying certain HLA alleles have been shown to be predisposed to certain autoimmune diseases, which may account in part for the genetic variability of autoimmunity. In addition, metabolites of a particular drug may vary between individuals to confound the development of drug-induced autoimmunity. Dendritic cells, such as the Langerhans cells of the skin and B lymphocytes that function to present antigens to Th cells, express class-II... [Pg.557]

Russel, A.S. (1981). Drug-induced autoimmune disease. Clin. Immun. Allergy 1 57. [Pg.593]

A 50-year-old woman with previous autoimmune thyroid disease taking atorvastatin developed acute hepatitis when she also was given ezetimibe (4). Further investigations, including liver biopsy, showed a probable drug-induced autoimmune hepatitis. [Pg.534]

While identification of autoimmunity hazard in preclinical safety assessment studies during the drug development seems not feasible, there is growing concern about drug-induced autoimmune diseases in human medicine. The gap between the lack of reliable experimental systems to identify such hazard and the increased focus on potential drug-induced autoimmunity has been recognized in the immunotoxicology community. [Pg.181]

Based on the short overview of the known animal models relevant to autoimmune diseases, it is quite clear the task of hazard identification and risk assessment for potential drug-induced autoimmunity is presently very difficult. There is no single in vivo model that can be used routinely to evaluate new drugs for autoimmunity induction. Nevertheless, some of the models could possibly be applied to test therapeutics with specific properties (e.g., off-target immunoregulatory activity) and concerns (e.g., patient population) in order to gain additional perspective and understanding of their role in autoimmune responses. [Pg.186]

Induction of autoimmune diseases by new therapeutics in humans is very rare. Similarly, drug-mediated autoimmunity in normal animals used in precfinical safety studies is hardly observed. In addition, due to a lack of predictive experimental systems (either in vitro or in vivo) as screening tools, presently the drug-induced autoimmunity hazard cannot be specifically identified. However, some input into risk assessment regarding the potential exacerbation of autoimmunity might be attainable for specific drugs. When possible signals are... [Pg.186]

Tan EM (1974) Drug-induced autoimmune disease. Fed Proc 33 1894 Territo MC, Peters RW, Tanaka KR (1973) Autoimmune hemolytic anemia due to levodo-pa therapy. JAMA 226 1347... [Pg.132]

Alkaline phosphatase levels and GGT are elevated in plasma with obstructive disorders that disrupt the flow of bile from hepatocytes to the bile ducts or from the biliary tree to the intestines in condition such as primary biliary cirrhosis, sclerosing cholangitis, drug-induced cholestasis, gallstone disease, and autoimmune cholestatic liver disease. [Pg.254]

Aucoin, D.P. Propylthiouriacil-induced immune mediated disease syndrome in The cat A novel model for a drug-induced lupus-like disease, in Autoimmunity and toxicology. Immune disregulation induced by drugs and chemicals. Kammuller, M.E., Bloksma, N. and Seinen, W., eds., Elsevier, Amsterdam, 1989, chap. 12. [Pg.484]

Nitrofurantion D-Penicillamine Peripheral neuritis Autoimmunity drug-induced SLE, myasthenia gravis, pemphigus, glomerulonephritis, Goodpasture s disease... [Pg.551]

The main causes are hepatitis B and C, drug induced damage, metabolic disease (alcohol, haemochro-matosis and Wilsons disease) and autoimmune disease. Management depends upon the diagnosis. [Pg.633]


See other pages where Drug-induced autoimmune disease autoimmunity is mentioned: [Pg.431]    [Pg.455]    [Pg.457]    [Pg.457]    [Pg.459]    [Pg.461]    [Pg.463]    [Pg.465]    [Pg.466]    [Pg.467]    [Pg.666]    [Pg.553]    [Pg.802]    [Pg.137]    [Pg.468]    [Pg.1799]    [Pg.2]    [Pg.57]    [Pg.80]    [Pg.149]    [Pg.315]    [Pg.180]    [Pg.203]    [Pg.227]    [Pg.162]    [Pg.166]    [Pg.59]    [Pg.456]    [Pg.472]    [Pg.628]    [Pg.551]    [Pg.558]    [Pg.448]   
See also in sourсe #XX -- [ Pg.463 ]




SEARCH



Autoimmune

Autoimmune diseases

Autoimmunity, drug-induced

Autoimmunization

Disease drug-induced

Drug-disease

Drug-induced

© 2024 chempedia.info