Acceptability, drug

A drug can also be linked to a delivery vector, which may render the drug acceptable to a BBB transport system. This linker can then be broken once the prodrug has penetrated the... 

One of the P T committee functions is to develop aformulary of drugs accepted for use in the hospital. The formulary is a continually revised compilation of drug products that reflects the current clinical judgment of the medical and pharmacy staffs. The selection... 

Medicinal teas with diuretic effect are usually a mixture of different drugs. Here only four will be dealt with. In France there are officially 21 drugs accepted for this purpose, in Germany 28 drugs. These diuretics are water diuretics , also called aquaretics , and suitable for irrigation therapy used for dysuric symptoms, catarrh of the bladder, to prevent relapse in urinary infection and prophylaxis of stones (concrements). 

Internet site with job bank www.miravant. com develops photodynamic drugs accepts e-mailed resumes... 

With several antipsychotic agents, bioavailability and drug acceptance by hospitalized patients is somewhat increased with liquid concentrates and rapidly disintegrating tablets that yield peak serum concentrations of chlorpromazine and other phenothiazines within 2— hours. Intramuscular administration avoids much of the first-pass enteric metabolism and provides measurable concentrations in plasma within 15-30 minutes. Bioavailability of chlorpromazine may be increased up to tenfold with injections, but the clinical dose usually is decreased by only three- to fourfold. 

Less abuse potential than C-lll drugs accepted medical use limited physical and psychological dependence written or verbal prescription, expires in 6 months max. 5 refills on one script... 

Esters for improving drug acceptability and reducing side effects 103... 

The utility of a protein model depends upon the use to which it is put. In some cases, on< only interested in the general fold that the protein adopts and so a relatively low-resoluti structure is acceptable. For other applications, such as drug design, the model must be me more accurate, including the loops and side chains. In such cases, a poor model may often fa r worse than no model at all, as it can be seriously misleading. 

Drugs. Ring-fluotinated aromatics have found broad pharmaceutical appHcations, eg, in tranquilizers, hypnotics, sedatives, antibacterial agents (qv), etc. Representative monofluorinated dmgs are Hsted in Table 4. Arprinocid [5579-18-15] is a fluoroaromatic-based veterinary dmg that has found wide acceptance as a coccidiostat for chicken feed. 

For present purposes, pyrimidines are considered to be important if they occur naturally as such or as part of a natural molecule from which the pyrimidine can be removed easily (fused pyrimidines, e.g. xanthine, are therefore excluded) if they are used as drugs if they are used as agricultural chemicals or if they have been given a generally accepted special name. Although a few pyrimidines are used as industrial chemicals for other purposes, e.g. in photography, these have assumed no great importance. 

The administration of some drugs for prophylactic and enhanced production purposes requires a period of withdrawal prior to slaughter of the animals and suitable analytical methods to ensure that their products are acceptable as food (Table... 

Fumigation with ethylene oxide does indeed lead to a considerable reduction in the germ count (and at the same time destruction of insects), but the process, because of the formation of toxic reaction products (ethylene chlorhydrin, ethylene glycol) has been banned throughout the European Community since 01.01.1990 Ionizing irradiation a declaration of the treatment is obligatory, but such drugs find little acceptance by the public who expect nature s products as such. 

In November 1997, the Department of Health and Human Services along with the International Conference on Harmonisation (ICH) released a draft guidance for the selection of test procedures, which included chiral drugs. For the development of an enantiopure drug substance, acceptable criteria shall include, if possible, an enan-tioselective assay. This assay should be part of the specification for the identification of an enantiopure drug substance and related enantioenriched impurities [16]. 

SMB is now accepted as a real production tool. For instance, the Belgium pharmaceutical company U.C.B. Pharma announced recently the use of SMB for performing multi-ton scale purification of an enantiopure drug substance. The concept of large-scale purification of enantiomers using chromatographic techniques has moved from a dream to a reality within the last few years. 

From the position of the FDA, acceptance of SMB as a viable tool for cGMP manufacturing of enantiopure drug substances, there shall be no compromise, it must be properly engineered, and follow established guidelines. 

International Conference on Harmonisation Draft Guidance on Specifications Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products Chemical Substances Notice, Fed Regist. Docket No. 97D-0448, 1997. 

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