Drowsiness vitamin

Nonpharmacologic therapy such as dietary, physical, and behavioral approaches should be considered first. Pyridoxine (vitamin B6) 10 to 25 mg three to four times daily alone or in combination with an antihistamine such as doxylamine is often used for NVP.9,11,12 This combination was previously marketed as Bendectin or Debendox but was withdrawn due to concerns over possible teratogenic effects, although the literature did not support this claim.11,12 Pyridoxine is well tolerated, but doxylamine and other antihistamines commonly cause drowsiness. For more severe NVP, promethazine, meto-clopramide, and trimethobenzamide may be effective and have not been associated with teratogenic effects.9... 

Common but usually transient side effects are lethargy, incoordination, blurred vision, higher cortical dysfunction, and drowsiness. At concentrations greater than 50 mcg/mL, phenytoin can exacerbate seizures. Chronic side effects include gingival hyperplasia, impaired cognition, hirsutism, vitamin D deficiency, osteomalacia, folic acid deficiency, carbohydrate intolerance, hypothyroidism, and peripheral neuropathy. 

Drowsiness, headache, dizziness, vertigo, seizures, confusion, psychosis, paresis, tremor, vitamin deficiency folate deficiency, cardiac arrhythmias, increased liver enzymes... 

The well-known dose-related side effects include gingival hyperplasia (due to altered collagen metabolism), cerebellar-vestibular effects (nystagmus, vertigo, ataxia), behavioural changes (confusion, drowsiness, hallucinations), increased seizure frequency, gastrointestinal disturbances (nausea, anorexia), osteomalacia (due to reduced calcium absorption and increased vitamin D metabolism) and megaloblastic anaemia (due to reduced folate absorption). 

Symptoms of overdose are due mainly to excessive rise in plasma calcium. General effects include malaise, drowsiness, nausea, abdominal pain, thirst, constipation and loss of appetite. Other long-term effects include ectopic calcification almost anywhere in the body, renal damage and an increased calcium output in the urine renal calculi may be formed. It is dangerous to exceed 10 000 units daily of vitamin D in an adult for more than about 12 weeks. 

Acute intoxication has been observed after ingestion of vitamin A-rich liver from the polar bear, halibut, or shark, or after the use of fish oil supplements used to lower plasma lipids. In adults, toxic doses have been in the range of one or more million units of vitamin A, but in children as low as 10 000 micrograms RE, or even in a few children under 650 micrograms RE/day (12). Symptoms occur at 6-24 hours after ingestion and include acute drowsiness, irritability, vertigo, headache, delirium and convulsions, intolerance of food, and diarrhea (SEDA-8, 344). 

Acute poisoning with vitamin A produces symptoms such as drowsiness, sluggishness, irritability, an irresistible desire to sleep, severe headache, and papilledema. In some cases papilledema is the only symptom (SEDA-11, 333) (16,17). In young children, raised intracranial pressure with bulging of the fontanelle, papilledema, and diplopia have been observed (SED-8,799, 801) (SEDA-15, 411) (18). 

Side effects Headaches, fatigue, drowsiness, nausea, heartburn, vomiting, diarrhea. Vitamin C with aspirin or sulfonamides may cause crystal formation in the urine (crystalluria) and can also cause a false negative occult (blood) stool result and false positive sugar result in the urine when tested by the Clinitest method. 

Gastric upset from CBZ may be diminished by taking the drug after meals. Common toxicities include blurred vision, dizziness, drowsiness, and ataxia. Tremor, depression, hyponatremia, and cardiac disturbances are seen at high serum concentrations. Idiosyncratic rashes are common rarer severe idiosyncratic effects include aplastic anemia, agranulocytosis, thrombocytopenia, and jaundice. Therefore, patients receiving CBZ should have periodic blood count determinations and liver function tests. Both CBZ and oxcarbazepine can reduce plasma 25-hydroxy vitamin D levels (45). CBZ increases levels of phenytoin and decreases levels of... 

Arnrich, 1978). Marie and See (1954) have described the symptoms of acute vitamin poisoning in children, vomiting, drowsiness, and bulging of the fontanelle. Table 1 documents that adults tend to complain of severe headaches, vertigo, abdominal pain, vomiting. 

In a 6-week study to evaluate the effectiveness of Vitamin D supplementation (vitamin D2 or D3 2000lU, or vitamin D2 50,000 lU weekly) compared with calcium for treatment of vitamin D sufficiency in children with inflammatory bowel disease was examined [49 ]. The most commonly reported events were nausea (n=6) increased thirst and loss of appetite (n=5 each) pruritus (n=4) drowsiness and increased urinary frequency (n=3 each) abdomirwl pain, hone pain, headache and constipation (n=2 each) rash, sensitive eyes, vomiting, irregular heartbeat, dry mouth and muscle pain (n=1 each). There were no significant differences in the frequency of adverse events between groups, and no serious adverse events were observed. 

The early symptoms of vitamin C deficiency are fatigue, lassitude, loss of appetite, drowsiness and insomnia, feehng run-down, irritability and low resistance to infections. Severe deficiency causes a weakening of these tissues (scurvy), resulting in capillary bleeding. Fish, like humans, are dependent on a vitamin C supply via the diet. The other food-producing animals are able to synthesize vitamin C themselves. However, under conditions of stress, this production may not be sufficient to support optimum health and performance. 

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