Drosophila conditions

Hryant But I don t think that in Drosophila we have the equivalent condition that Andy McMahon is talking about, where in the absence of genes there is no growth. The situations you mention just involve change of the overall fate. 

Most of the viral vectors were constructed using (1) the Autographa californica nuclear polyhedrosis virus (AcNPV), which is able to infect moth species, Spodoptera frugiperda ovarian cell lines and, in specific conditions, Drosophila cells (2) the Bombyx mori nuclear polyhedrosis virus (BmNPV), which is able to infect silkworm cells. To broaden the range of infection of hosts, a hybrid virus was generated [118,119]. 

Sierra, L.M., A.R. Barros, M. Garcia, J.A. Ferreiro, and M.A. Comendador. 1991. Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions. Mutat. Res. 260 247-256. 

Enzymatically active PARP molecules have also been found involved in transcription in undamaged cells. Recent research on Drosophila has demonstrated that active puff loci are rich in PARPl and ADPR polymers, this being the necessary condition to induce chromatin decondensation and gene expression [159]. Mechanism of PARPl-mediated puffing and chromatin remodeling reinforces the idea previously suggested by Althaus to explain the role played by PARPl in DNA repair [160]. 

Further work is being conducted using specialized yeasts and other species of Drosophila and quantifying differences in hydrolysis and toxicity of glycosides under these conditions. 

Dietzl G, Chen D, Schnorrer F, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448,151-6. 

In a test for sex-linked recessive lethal mutations in Drosophila, Wild et al. 8 found no evidence of mutagenicity of CS. More than 9,000 chromosomes were tested, and the frequencies of mutations in the treated groups did not differ from those in the concurrent negative controls or the historical negative controls. The available information on the toxicity of CS under the treatment conditions is minimal. The actual dosages received by the flies are also uncertain, particularly because CS breaks down rapidly in water. Nevertheless, the available data give no indication of mutagenicity of CS in Drosophila. 

Kitamoto T. (2001) Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J. Neurobiol. 47, 81-92. 

---