Doxorubicin Mercaptopurine

DOXORUBICIN MERCAPTOPURINE t risk of hepatotoxicity due to mercaptopurine Uncertain, possibly due to previous treatment with mercaptopurine Avoid co-administration - except in clinical trials... [Pg.300]

In Fig. 1 various targets of some important cytostatic agents are depicted. Their main mechanisms of action can be briefly summarized as follows. Pentostatin blocks purine nucleotides by inhibiting adenosine deaminase. 6-Mercaptopurine and 6-thioguanine inhibit purine ring biosynthesis and they inhibit nucleotide interconversions. Methotrexate by inhibiting dihydrofolate reduction blocks thymidine monophosphate and purine synthesis. 5-Fluorouracil also blocks thymidine monophosphate synthesis. Dactinomycin, daunorubicin, doxorubicin and mitoxantrone intercalate with DNA and inhibit RNA synthesis. L-asparaginase deaminates... [Pg.448]

Acute lymphocytic leukemia Induction vincristine plus prednisone. Remission maintenance mercaptopurine, methotrexate, and cyclophosphamide in various combinations Asparaginase, daunorubicin, carmustine, doxorubicin, cytarabine, allopurinol,1 craniospinal radiotherapy... [Pg.1310]

Choriocarcinoma (trophoblastic neoplasms) Methotrexate alone or etoposide and cisplatin Vinblastine, mercaptopurine, chlorambucil, doxorubicin... [Pg.1312]

Sulfuric acid and potassium permanganate are used to dispose of doxorubicin or daunorubicin wastes. Doxorubicin shows mutagenicity only at high concentrations. Care must be exercised by wearing protective clothing when handling urine and feces after administration of doxorubicin, etoposides, fluorouracil, methotrexate, mitoxantrone, mustine, procarbazine, melphalan, mercaptopurine, vinblastine, vincristine, and hydroxyurea.217... [Pg.361]

Clinically important, potentially hazardous interactions with altretamine, amikacin, aminoglycosides, antineoplastics, bleomycin, busulfan, carboplatin, carmustine, chlorambucil, cisplatin, corticosteroids, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, docetaxel, doxorubicin, estramustine, etoposide, fludarabine, fluorouracil, gemcitabine, gentamicin, hydroxyurea, idarubicin, ifosfamide, indomethacin, kanamycin, levamisole, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitotane, mitoxantrone, neomycin, pentostatin, plicamycin, procarbazine, streptomycin, streptozocin, thioguanine, thiotepa, tobramycin, tretinoin, uracil, vinblastine, vincristine, vinorelbine... [Pg.13]

Ara-C, cytarabine ASP, asparaginase CALGB, Cancer and Leukemia Croup B CNS, centrai nervous system CTX, cyciophosphamide DEX, dexamethasone DNR, daunorubicin DOX, doxorubicin iT, intrathecai /y p mercaptopurine MTX, methotrexate PRED, prednisone TC, thioguanine VCR, vincristine. [Pg.2492]

While emphasis has been given to the use of anti-metabolites in the treatment of acute lymphoblastic leukaemia in children, they are also used with varying success with other types of cancer. For the other common forms of leukaemias - acute myeloid and monocytic leukaemias - which affect adults in the age range 55-75, a cocktail of drugs that includes cytarabine, 6-thioguanine (an analogue of 6-mercaptopurine) and daunorubicin (a structural relative of doxorubicin, discussed later) can induce remission in up to 80% of patients. Bone-marrow transplantation has also become a standard part of the treatment, once remission has been achieved, and the resultant rate of cure is usually around 50%, especially in patients under 65 years. [Pg.175]

Acute lymphoid leukemia During the initial phase, vincristine and prednisone are used methotrexate and mercaptopurine are used for maintenance therapy in addition, methotrexate is given intrathecaUy, with or without radiotherapy, to prevent meningeal leukemia Diffuse histiocyte lymphoma Cyclophosphamide, vincristine, methotrexate, and cytarabine (COMA) Mycosis fungoides Methotrexate Squamous cell, large-cell anaplastic, and adenocarcinoma Doxorubicin and cyclophosphamide, or methotrexate... [Pg.284]

Characteristics Nucleotide analogues Anticancer drugs 6-mercaptopurine Cyclic nucleotides cyclic AMP, cyclic GMP HIV protease inhibitors adefovir Anticancer drugs doxorubicin, etoposide ... [Pg.37]

Acute lymphocytic leukemia Induction vincristine plus prednisone plus asparaginase plus doxorubicin with or without cyclophosphamide. Maintenance mercaptopurine plus methotrexate... [Pg.481]

A number of case reports describe an increase in the effects of warfarin, accompanied by bleeding in some cases, caused by an-tineoplastic regimens containing carboplatin, chlormethine, cyclophosphamide, doxorubicin, etoposide, gefitinib, gemcitabine, ifosfamide with mesna, methotrexate, procarbazine, trastuzum-ab, vincristine or vindesine. A decrease in the effects of warfarin has been seen with azathioprine, cyclophosphamide, mercaptop-urine and mitotane, a decrease in the effects of acenocoumarol has been seen with mercaptopurine, and a decrease in the effects of phenprocoumon have l n seen with azathioprine. [Pg.382]

One study postulated that the hepatotoxicity of intravenous mercaptopurine can be increased by doxorubicin. [Pg.666]

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