Acute lymphoid leukemia

Acute lymphoid leukemia During the initial phase, vincristine and prednisone are used. Methotrexate and mercaptopurine are used for maintenance therapy. In addition, methotrexate is given intrathecally, with or without radiotherapy, to prevent meningeal leukemia. 

Mercaptopurine is used in the treatment of acute lymphoid leukemia. Maintenance therapy makes use of both methotrexate and 6-mercaptopurine. Mercaptopurine is absorbed well from the gastrointestinal tract. It is metabolized through (1) methylation of the sulfhydryl group and subsequent oxidation, and (2) conversion to 6-thiouric acid with the aid of xanthine oxidase, which is inhibited by allopurinol. Mercaptopurine may cause hyperuricemia. Its chief toxicities are hepatic damage and bone marrow depression. 

Acute lymphoid leukemia In the induction phase, vincristine is used with prednisone. 

Murphy JL. Renal tubular acidosis In children treated with trimethoprim-sulfamethoxazole during therapy for acute lymphoid leukemia. Pediatrics. 1992 Jun 89(6 Pt 1) 1072-4. 

Torelli G, Grosveld G. Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript. Blood 1990 75 1146-53. 

Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002 100 1965-1971. 

Application of MIDGE Vectors and dSLIM in DNA-based Immunization against Acute Lymphoid Leukemia... 

Patients with Philadelphia chromosomepositive (Ph ) acute lymphoid leukemia (ALL) exhibit a poor prognosis. Tumor cells of these patients express BCR-ABLPi , a fusion protein with intrinsic and constitutive tyrosine kinase activity that is responsible for the mahgned phenotype of the affected cells. 

Fig. 7.13 Cell-based vaccination against acute lymphoid leukemia in a murine model. Syngeneic mice were immunized via prime/boost scheme with BM185 tumorigenic cells that had been transfected with MIDGE vectors encoding CD80/B7.1 and GM-CSF either with addition of dSLIM (blue circles) or...

Acute lymphoid leukemia, see ALL Acute myelogenous leukemia (AML) 502... 

Vincristine in sphingomyelin- Improved delivery Acute lymphoid leukemia... 

Treatment of acute lymphoid leukemia with combination chemotherapy including vincristine (Bernard)... 

These data indicate that the biochemical heterogeneity within the spectrum of lymphoid proliferation is identical in the self limiting proliferation in IM (table 1) and in T-cell acute lymphoid leukemia (2). Myeloid proliferation differs from these lymphoid proliferations in the normal PNP activity (table 1). 

---