Docusates

Docusate Calcium. Dioctyl calcium sulfosuccinate [128-49-4] (calcium salt of l,4-bis(2-ethylhexyl)ester butanedioic acid) (11) is a white amorphous soHd having the characteristic odor of octyl alcohol. It is very slightly soluble in water, and very soluble in alcohol, polyethylene glycol 400, and com oil. It may be prepared directly from dioctyl sodium sulfo succinate dissolved in 2-propanol, by reaction with a methan olic solution of calcium chloride. [Pg.201]

Docusate calcium is used both as a fecal softening agent and an emulsifier, ie, a wetting or dispersing agent for external preparations (see Emulsions). [Pg.201]

Docusate Sodium. Aerosol OT, Colace, and Doxinate are trade names of docusate sodium [577-11-7] (dioctyl sodium sulfo succinate, sodium salt of l,4-bis(2-etliylhexyl)estet butanedioic). This white, wax-like, plastic sohd, with a characteristic odor suggestive of octyl alcohol, is usually available in the form of pellets. One gram of the sodium salt slowly dissolves in about 70 mL water. Docusate sodium is freely soluble in alcohol and glycerol, very... [Pg.201]

Docusate sodium is both a surface-active agent for use as a fecal softener, and a wetting agent in industrial, pharmaceutical, cosmetic, and food apphcations. [Pg.202]

Cadmium chloride Naproxen Calcium bisulfite obesilate calcium Calcium carbonate Caraspirin calcium Medazepam Calcium chloride Docusate calcium Fibrinolysin Calcium ferricyanide Sulfamethizole Calcium hydroxide Cyclamate calcium Inositol... [Pg.1619]

Dimethyl sulfoxide 1 -Dimethyl-1,4,5,6-tetrahydro-pyrimidine Pyrantel pamoate 3,5-Dinitrobenzoic acid Diatrizoate sodium Dioctyl sodium sulfosuccinate Docusate calcium... [Pg.1631]

Dow-lsoniazid Isoniazid Dowmycin - Erythromycin Dow-Sulfisoxazole - Sulfisoxazole Doxal - Doxepin HCI Doxaprii - Doxapram HCI Doxedyn - Doxepin HCI Doxergan - Dxomemazine Doxidan Docusate calcium Doxi-OM - Dobesilate calcium Doxitard -Doxycycline Doxium - Dobesilate calcium Doxy - Doxycycline Doxy 200 - Doxycycline Doxylin - Doxycycline Doxy-Puren - Doxycycline Doxyremed - Doxycycline Doxytrex - Dobesilate calcium... [Pg.1694]

Fecal Softeners Sjrfactants docusate sodium Co lace, D-S-S Follow directions on the... [Pg.470]

Fiscal softeners promote water retention in the fecal mass and soften the stool. One difference between emollient laxatives and fecal softeners is that the emollient laxatives do not promote the retention of water in the stool. Examples of fecal softeners include docusate sodium (Cblace)and docusate caldum (Surfak). [Pg.475]

DDS 100 Plus Capsules—docusate, casanthranol Doxidan Capsules—docusate, casanthranol, sorbitol Nature s Remedy—cascara sagrada, aloe, lactose Peri-Colace—docusate, casanthranol, sorbitol, parabens Senokot-S tablets—docusate, senna concentrate, lactose... [Pg.682]

Also known as surfactants and stool softeners, emollients (e.g., salts of docusate) act by increasing the surface wetting action on the stool leading to a softening effect. They reduce friction and make the stool easier to pass. These agents are not recommended for treating constipation of long duration. [Pg.310]

The answer is c. (Hardman, p 924.) Dioctyl sodium sulfosuccinate (docusate) is a detergent that, when given orally, softens the stool and prevents straining. Mineral oil also softens the stool, but it tends to inhibit the absorption of fat-soluble vitamins and other nutrients. Castor oil, phenol-phthalein, and cascara sagrada are strong laxatives and cause watery stools... [Pg.235]

These surfactant agents, docusate in its various salts, work by facilitating the mixing of aqueous and fatty materials within the intestinal tract. They may increase water and electrolyte secretion in the small and large bowel. [Pg.267]

Mineral oil is helpful in situations similar to those suggested for docusates to maintain a soft stool and avoid straining for relatively short periods of time (a few days to 2 weeks). [Pg.267]

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