Docetaxel anticancer

Syrigos KN, Michalaki B, Alevyzaki F, et al. A phase II study of liposomal doxorubicin and docetaxel in patients with advanced pancreatic cancer. Anticancer Res 2002 22 3583. 

Anticancer drugs Paclitaxel Docetaxel Vinblastine Vincristine Tipifarnib Diflomotecan Iiinotecan Doxorubicin Daunorubicin Etoposide Tenoposide Tamoxifen (i)... 

As will be mentioned further in this chapter, the discovery of the anticancer drug, paclitaxel (21), was soon followed by sourcing issues due to the low yield of this compound in the source plant, Taxus brevifolia Nutt. This led to the semisynthesis of paclitaxel (21), from a precursor molecule, 10-deacetylbaccatin III, readily available from the leaves of Taxus baccata L., a renewable source with high yields of this compound.Docetaxel (37) is a second taxane class anticancer drug and is a semisynthetic derivative of paclitaxel (21). ... 

Varveris H, Delakas D, Anezinis P, et al. Concurrent platinum and docetaxel chemotherapy and external radical radiotherapy in patients with invasive transitional cell bladder carcinoma. A preliminary report of tolerance and local control. Anticancer Res 1997 17(6D) 4771 1780. 

Koukourakis MI, Bizakis JG, Skoulakis CE, et al. Combined irinotecan, docetaxel and conventionally fractionated radiotherapy in locally advanced head and neck cancer. A phase I dose escalation study. Anticancer Res 1999 19(3B) 2305-2309. 

The in vitro system has some limitations and it can be used only as a model to address acquired drug resistance, because cell lines may not accurately reflect the in vivo situation of patients treated with anticancer drugs. In vivo analysis using patient samples to study anti-cancer drug resistance are described in the published literature. Chang and coworkers (64) showed that the gene-expression patterns from mRNA derived from needle biopsies of breast cancer patients treated with the anticancer drug, docetaxel, could be predictive of response to the therapy. 

A camphor lactam imide auxiliary has also been used in a similar fashion (equation 124)501. Using this type of protocol, but replacing the aldehyde with an imine, the docetaxel (an important anticancer compound related to taxol) side chain has been... 

In this chapter, we describe an account of our research on the chemistry and biology of paclitaxel and taxoid anticancer agents (taxoid = taxol-like compound). The topics covered in this chapter include (i) the development of a practical and efficient method for the semisynthesis of paclitaxel and docetaxel using chiral 3-hydroxy-P-lactams as synthetic intermediates, (ii) structure-activity relationship (SAR) studies of various taxoids that led to the discovery of the extremely potent second-generation taxoids, and (iii) biological and conformational studies with the use of fluorine-containing taxoids as probes. ... 

It is very important to clarify the minimum structural requirements for paclitaxel and taxoids to exhibit anticancer activity by looking at simplified structure analogues. Along this line, we have investigated the role of the A ring by synthesizing novel nor-seco analogues of paclitaxel and docetaxel.37,96... 

Heike Y, Hosokawa M, Osumi S, Fujii D, Aogi K, Takigawa N, et al. Identification of serum proteins related to adverse effects induced by docetaxel infusion from protein expression profiles of serum using SELDI ProteinChip system. Anticancer Res 2005 25(2B) 1197-1203. 

Pei, J., Zhang, C., Gokhale, PC., Rahman, A., Dritschilo, A., Ahmad, I., and Kasid, U. (2004) Combination with liposome-entrapped, ends-modified raf anti-sense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cis-platin, epirubicin, mitoxantrone, docetaxel, and gemcitabine. Anticancer Drugs 15, 243-253. 

Taxine alkaloids are complex polycyclic compounds in which N is present but not as an integral part of a ring. The taxines are found in Taxus (yew) species (Taxaceae). Taxine A (C61 CIO ] C6-0-C0-CH(0H)-CH(N(CH3)2)-Phe) is substantially responsible for yew toxicity. The related polycyclic amide taxol (paclitaxel) and the closely related docetaxel are tubulin-binding, antimitotic cytotoxics that are used clinically as anticancer drugs. A variety of taxines have been isolated from Taxus species. 

Although paclitaxel was reported to be effective against ovarian and breast cancers resistant to other first-line anticancer drugs in clinics, the patients often relapsed and did not respond to these antimmor agents, including pachtaxel, anymore. Unfortunately, docetaxel was also inactive toward paclitaxel-resistant tumors. 

Paclitaxel (Taxol Bristol Myers Squibb 14) and its semisynthetic analog docetaxel (15) are two of the most important anticancer agents of the last 25 years. Paclitaxel was isolated originally by Wall and Wani from Taxus brevifolia (23) and named taxol this name was later trademarked by Bristol-Myers... 

Salminen E, Bergman M, Huhtala S, Jekunen A, Ekholm E. Docetaxel, a promising novel chemotherapeutic agent in advanced breast cancer. Anticancer Res 2000 20(5C) 3663-8. 

Cardoso F, Ferreira FUho AF, Crown J, Dolci S, Paesmans M, Riva A, Di Leo A, Piccart MJ. Doxorubicin followed by docetaxel versus docetaxel followed by doxorubicin in the adjuvant treatment of node positive breast cancer results of a feasibihty study. Anticancer Res 2001 21(lB) 789-95. 

Shin E, Ishitobi M, Hiraoia M, Kazumasa F, Hideyuki M, Nishisho I, Toshiro S, Yasunori H, Tosimasa T. Phase I study of docetaxel administered by bi-weekly infusion to patients with metastatic breast cancer. Anticancer Res 2000 20(6C) 4721-6. 

Ekholm E, Rantanen V, Bergman M, Vesalainen R, Antila K, Salminen E. Docetaxel and antonomic cardiovascular control in anthracycline treated breast cancer patients. Anticancer Res 2000 20(3B) 2045-8. 

Taxus (yew) trees contain alkaloids called taxanes that have anticancer activity and are the basis of the semisynthetic anticancer drugs paclitaxel and docetaxel (see separate monographs), which are based on taxol, from Taxus brevifolia. 

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