Structural requirements, minimum

Plastic products should be designed with the minimum wall thickness that will provide the specified structural requirements. This results in saving material and higher molding... 

However, although electrochemistry can be used for the above, it will do so only if this functionality is designed into the structure. At minimum, two requirements... 

Precise investigation on the relationship between chemical structures and biological activities, and elucidation of minimum structural requirements for the activities. 

At first, only two conflict objectives are considered the minimal utility consumption and the maximal flexibility to all source-stream temperatures. And then the third objective, the minimal number of matches, would be appended. Results of two-phase fuzzy optimization with preference intervals of [2550, 12750] or [2550, 8850] for utility, [0, 150], [40, 90] or [40, 70] for flexibility, and [4, 7] for unit numbers, along with either or not considering restrictions on heat loads at extreme operating points, are listed in Table 4. The resulting HEN structures are also depicted in Fig. 2. Notably, the reduced range of flexibility, [40, 90], implies that the required minimum tolerance for temperature deviation is at least 40 K and a tolerance of maximum temperature deviation for 90 K... 

D. Nor-Seco Taxoids Probing the Minimum Structural Requirements... 

VI. NOR-SECO TAXOIDS PROBING THE MINIMUM STRUCTURAL REQUIREMENTS FOR ANTICANCER ACTIVITY... 

It is very important to clarify the minimum structural requirements for paclitaxel and taxoids to exhibit anticancer activity by looking at simplified structure analogues. Along this line, we have investigated the role of the A ring by synthesizing novel nor-seco analogues of paclitaxel and docetaxel.37,96... 

The average Al203/Mg0 ratio for 24 illites is 9.6 and for 101 montmorillonites 6.7. Attapulgite values range from 2.5 to 0.48. The ratios of octahedral Al/octahedral Mg are respectively 5.4, 4.3 and 1.8-0.4. Radoslovich (1963b) found that the 2M muscovite structure required a minimum of 1.7 of the three octahedral sites be filled with Al. The Al occurs in the two symmetrically related sites and the larger divalent cation occurs in the distinctive or unoccupied site. The lower limit of 1.7 Al is equivalent to 85% of the two symmetrically related or occupied sites being filled in a stable muscovite structure. A similar restriction is reported for the trioctahedral micas where an upper limit of 1.00 (R3++ R4+)per three sites was found by Foster (1960). 

These screening approaches require minimum information for the evaluation of pharmaceutically relevant properties. Compounds that do not meet a predetermined criterion are eliminated from further consideration. Guidance is obtained for further structure optimization via synthetic modification. Thus, pharmaceutical properties are assessed on the timescale of compound synthesis, resulting in an optimization while programs are still active. Therefore, unfavorable candidates are eliminated early and resources are focused on more promising drug candidates. 

Since we feel that perhaps better results can be obtained from another viewpoint, we propose to consider the mechanism of action by an approach considering the minimal structural requirements necessary to bring about hormonal activity. We must remember that the natural androgen and anabolic agent, testosterone, does not display the minimum structural requirements of active steroids —there are many steroids which are less active testosterone itself is an excellent androgen and a good anabolic agent. 

In conclusion, the disaccharide Gaipi-4GlcNAc appears to be the minimum structure required for binding of ToxA. No receptor structure for ToxB has yet been identified. 

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