7,12-Dimethylbenz anthracene DMBA-induced mammary

Singletary, K.W., and J.M. Nelshojjpen. 1991. Inhibition of 7,12-dimethylbenz[ ]anthracene (DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract. Cancer Lett. 60(2) 169-175. 

As mentioned earlier that sesame lignans, especially sesamin and epi-sesamin, could influence the metabolism of polyunsaturated fatty acid and the production of prostaglandins. As prostaglandin is one of the most influential factors for mammary carcinogenesis, Hirose et al. (99) studied the effect of sesamin on dimethylbenz-anthracene (DMBA)-induced mammary cancer. Their results showed that sesamin at a dietary level of 0.2% considerably reduced the cumulative number and mean number of mammary cancer the effectiveness of sesamin was similar to a-tocopherol. 

Li S, Levesque C, Geng CS, Yan X, Labrie F (1995) Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (El)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat. Breast Cancer Res Treat 34 147-159... 

Constantinou AI, Mehta R, Husband A. (2003) Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. Fur J Cancer 39 1012-1018. 

In vivo, letrozole (3) was efficacious in two animal models. One was a postmenopausal hormone-dependent breast cancer mouse model, the other was a dimethylbenz[a]-anthracene (DMBA)-induced mammary carcinoma rat model. 

Dimethylbenz( a) anthracene (DMBA)-induced mammary carcinoma in the rat is a widely used animal model to study the factors that control hormone-sensitive breast cancer in women. In fact, the development and growth of these tumors are particularly sensitive to the stimulatory action of estrogen and prolactin (Asselin et al., 1977 Asselin and Labrie, 1978 Dauvois and Labrie, 1990 Dauvois et al., 1989b Huggins et al., 1961 Jordan and Allen, 1980 Kelly et al., 1977, 1979 Labrie et al., 1976, 1993 Leung etal., 1975 Li et al., 1993, 1995 Welsch, 1985). 

Fig. 19. Effect of treatment with dehydroepiandrosterone (DHEA) (10 mg, percuta-neously, once daily) or EM-800 (75 pg, orally, once daily) alone or in combination for 9 months on the incidence of dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma in the rat throughout the 279-day observation period. Data are expressed as percentage of the total number of animals in each group (Luo et al., 1997c).

Mam-2 Inhibition of 7,12-dimethylbenz[a (anthracene (DMBA) induced mammary tumors... 

Singletary, K., MacDonald, C., Walhg, M., and Fisher, C., Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and DMBA-DNA adduct formation by curcumin. Cancer Lett, 103 (2), 137-141,1996. 

The furanoids, kahweol and cafestol, isolated from green coffee beans (4) have been found to induce increased GST activity and inhibit 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary tumor formation (9) and hamster cheek pouch carcinogenesis (10,11). The presence of the fiiran moiety was determined to be essential for enzyme induction. When the furan ring in cafestol was saturated by hydrogenation, its activity as a GST enzyme inducer was lost (S). 

Jung KJ, Wallig MA and Singletary KW. 2006. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233 279-288. 

My interest in the influence of diet on hormone-dependent cancers was first stimulated about 20 years ago by studies carried out in collaboration with colleagues at the Collip Medical Research Laboratory of the University of Western Ontario. They were involved in studies on the role of hormones in mammary cancer and for this purpose were inducing tumors in rats with 7,12-dimethylbenz(oi)-anthracene (DMBA) as described by Huggins et al ( 1). They were concerned to know whether hormonal treatment might affect tumorigenesis by altering the degree and time of exposure of mammary... 

Resveratrol has been shown to inhibit proliferation, induce differentiation, and enhance the expression of adhesion molecules (GDI la, GDI lb, GDIS, GD54) in a variety of myeloid leukemia cell lines [144]. The inhibitory effect of resveratrol on cell survival and proliferation of human breast cancer cells was shown to be estrogen receptor dependent [145]. Other studies indicated that it was very effective in inhibiting growth of 4T1 breast cancer cells in culture but had little effect on 4T1 tumor cell growth in mice [146]. In stark contrast, resveratrol was tested against mammary tumors induced by 7, 12-dimethylbenz(a)anthracene (DMBA) in rats [147]. In this case, reductions in incidence, multiplicity, and latency period of tumor development were observed. Additional... 

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