Dimethylamino methacrylate

Molecular imprinting can be accomplished in two ways (a), the self assembly approach and (b), the preorganisation approach3. The first involves host guest complexes produced from weak intermolecular interactions (such as ionic or hydrophobic interaction, hydrogen bonding) between the analyte molecule and the functional monomers. The self assembled complexes are spontaneously formed in the liquid phase and are sterically fixed by polymerisation. After extraction of the analyte, vacant recognition sites specific for the imprint are established. Monomers used for self assembly are methacrylic acid, vinylpyridine and dimethylamino methacrylate. 

Styrene monomer was also copolymerized with a series of functional monomers by using a single-step dispersion copolymerization procedure carried out in ethanol as the dispersion medium by using azobisizobu-tyronitrile and polyvinylpyrollidone as the initiator and the stabilizer, respectively [84]. The comonomers were methyl methacrylate, hydroxyethyl acrylate, metha-crylic acid, acrylamide, allyltrietoxyl silane, vinyl poly-dimethylsiloxane, vinylsilacrown, and dimethylamino-... 

The nonionic monomer can be acrylamide, N,N-dimethylacrylamide, N-vinyl-2-pyrrolidone, N-vinyl acetamide, or dimethylamino ethyl methacrylate. Ionic monomers are AMPS, sodium vinyl sulfonate, and vinylbenzene sulfonate. The terpolymer should have a molecular weight between 200,000 to 1,000,000 Dalton. 

N-vinyl acetamide, or dimethylamino ethyl methacrylate, 2-acrylamido-2-methylpropane sulfonic acid, sodium vinyl sulfonate, and vinylbenzene sulfonate... 

Hydrophobic polymers with some hydrophilic groups can be obtained with an emulsion polymerization technique. Suitable monomers are nitrogen-containing acrylics and methacrylics allyl monomers such as dimethylamino-ethyl methacrylate, dimethylaminopropyl methacrylamide, diethylamino-ethyl methacrylate, dimethylaminoethyl acrylate, diethylaminoethyl acrylate and nitrogen-containing allyl monomers (e.g., diallylamine and N,N-diallyl-cyclohexylamine) [225,226]. 

New drug delivery systems are of great scientific and commercial interest. Amphiphilic networks composed of about 50/50 hydrophobic PIB and hydrophilic poly(2-(-dimethylamino)ethyl methacrylate) (DMAEMA) polymer segments were found to be biocompatible and to a large extent avascular (7). These PHM-PDMAEMA networks (i, in line with propositions of Weber and Stadler (2), and Sperling (J), denotes PDMAEMA chains linked by PIB chains) gave pH dependent... 

Ishii T, Otsuka H, Kataoka K, Nagasaki Y (2004) Preparation of functionally Pegylated gold nanoparticles with narrow distribution through autoreduction of auric cation by alpha-biotinyl-PEG-block-[poly (2-(N, N-dimethylamino) ethyl methacrylate)]. Langmuir 20 561-564... 

Poly[2-(dimethylamino)ethyl methacrylate-block- methyl methacrylate] copolymer, 20 485... 

In this study, we demonstrate new pH/temperature-sensitive polymers with transitions resulting from both polymer-polymer and polymer-water interactions and their applications as stimuli-responsive drug carriers [22-23], For this purpose, copolymers of (Ai,Ai-dimethylamino)ethyl methacrylate (DMAEMA) and ethylacrylamide (EAAm) [or acrylamide (AAm)] were prepared and characterized as polymeric drug delivery systems modulated for pulsatile and time release. 

The first diblock copolymer brushes synthesized in our group were made by a combination of carbocationic polymerization and ATRP (Scheme 1) [46]. Zhao and co-workers [47] synthesized diblock copolymer brushes consisting of a tethered chlorine-terminated PS block, produced using carbocationic polymerization, on top of which was added a block of either PMMA, poly(methyl acrylate) (PMA) or poly((Ar,M -dimethylamino)ethyl methacrylate) (PDMAEMA), synthesized using ATRP. The thickness of the outer poly(meth)acrylate block was controlled by adding varying amounts of free initiator to the ATRP media. It has been reported that the addition of free initiator is required to provide a sufficiently high concentration of deactivator, which is necessary for controlled polymerizations from the sur-... 

PS—polystyrene, PMMA—poly(methyl methacrylate), PMA—poly(methyl acrylate), PDMAEMA—poly((Nd f-dimethylamino)ethyl methacrylate), PDMA—poly( dimethyl-acrylamide), P(t-BA)—poly(tert-butyl acrylate), PAA—poly(acrylic acid), PPFS—poly (pentafluorostyrene), PHFA—poly(heptadecafluorodecyl acrylate)... 

We have recently evaluated the ATRP of a wide range of hydrophilic monomers such as 2-sulfatoethyl methacrylate (SEM), sodium 4-vinylbenzoate (NaVBA), sodium methacrylate (NaMAA), 2-(dimethylamino)ethyl methacrylate (DMA), 2-(iV-morpholino)ethyl methacrylate (MEMA), 2-(diethylamino)ethyl methacrylate (DEA), oligo(ethylene glycol) methacrylate (OEGMA), 2-hydroxyethyl methacrylate (HEMA), glycerol monomethacrylate (GMA), 2-methacryl-oyloxyethyl phosphorylcholine (MPC), and a carboxybetaine-based methacrylate [CBMA]. Their chemical structures and literature references (which contain appropriate experimental details) are summarised in Table 1. 

Citrate-capped Au NPs have been coated with a layer composed of the double hydrophilic block copolymer polyethylene oxide)-block-poly(2-(dimethylamino)eth-yl methacrylate)-SH (PEO-b-PDMA-SH) leading to core-shell, almost spherical, Au NPs of about 18 nm. The shell cross-linking of these hybrid Au NPs gives rise to high colloidal stability [122]. 

Graft copolymers of polyamides using pre-irradiation gamma-rays techniques have been reported for styrene (130), in solution, in the presence of water (40), in alcohols or acetone solution (131), vinyl acetate (130), methacrylic acid in water (132) or methanol solution (129), methyl (133) and ethyl (130) acrylates, 2-ethylhexyl acrylate (55,134), methyl methacrylate (130), in methanol solution (129), 2-dimethylamino ethyl methacrylate quaternary salts (135), acrylamide in aqueous medium (128,136), acrylonitrile (130,137), and 4-vinyl pyridine in aqueous solution (128). 

Racemic 1-phenylethyl methacrylate is resolved efficiently by a cy-clohexylmagnesium chloride-(—)-sparteine complex to give, at 70% conversion, optically active polymer and the unreacted monomer in greater than 90% ee (181). Similarly, reaction of racemic phenyl-2-pyridyl-o-tolylmethyl methacrylate in the presence of 4-fluorenyllithium and (+)- or (—)-2,3-dimethoxy-l,4-bis(dimethylamino)butane proceeds with a high degree of kinetic resolution (182). 

N,N-D imethytamino)ethyl methacrylate, A017 U-(Dimethylamino)iodobenzene, AN39 a-(D imethylami no)i sobutyra 1 dehyde,... 

Dopant orientation during and following electric field-induced poling can be studied continuously and in real time in order to examine the microenvironment surrounding the dopants in terms of the polymer relaxations and the applied corona field. In the results presented below, the SHG of 4-dimethylamino-4 -nitrostilbene (DANS) dispersed in polystyrene (PS) or poly(methyl methacrylate) (PMMA) matrices has been examined in corona poled films as a function of temperature in order to understand the effect of thermal conditions on the temporal stability of the dopant orientation. 

Chemg, J.Y., van de Wetering, P., Talsma, H., Crommelin, D.J. and Hennink, W.E. (1996) Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino) ethyl methacrylate)-plasmid nanoparticles. Pharm. Res., 13, 1038-1042. 

Chemg, J.-Y., Schuurmans-Nieuwenbroek, N.M.E., Jiskoot, W., Talsma, H., Zuidam, N.J., Hennink, W.E. and Crommelin, D.J.A. (1999a) Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes. J. Control. Release, 60, 343-353. 

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