Polymeric drug delivery systems

Figure 6 also shows that the use of this polymeric delivery system, also known as the BIODEL polymeric drug delivery system, for BCNU greatly increases the time over which the brains of these animals are exposed to significant BCNU concentrations. The brains... [Pg.53]

Interactions between Polymeric Drug Delivery Systems and Biological Systems Barriers and Opportunities... [Pg.40]

In general, the performance of any polymeric drug delivery system is highly dependent on both the therapeutic result desired and the milieu in which the system must operate. Both of these considerations are set by the interaction between the delivery system and the biological system in which it must operate. Most drug delivery systems, then, are intended to achieve one of the following three goals ... [Pg.40]

In this chapter an overview of both the opportunities and the problems presented by the biological system for the use of polymeric drug delivery systems will be presented. Since the area of biocompatibility of the delivery system is a well-known constraint also imposed by the biological system and is beyond the scope of this presentation, this (important) consideration will be ignored here. In order to examine how a delivery system interacts with the biological system to... [Pg.40]

Two basic questions arise from the biological system (excluding the route of administration discussed above) when the use of a polymeric drug delivery system is contemplated ... [Pg.42]

In this paper, then, the previously developed model (7) is extended to the calculation of erosion characteristics of a well described polymeric delivery system, the acid-catalyzed erosion of poly (ortho ester)s (2-6). This system is chosen as the example system because of the completeness of the data package in the open literature. It is expected that this modelling approach is also useful for other hydrolytically unstable polymeric drug delivery systems. [Pg.171]

A mathematical model has been developed which allows the calculation of the degradation of polymeric drug delivery systems. The model has been shown to accurately simulate both the drug release and molecular weight changes in such systems. The concentration of anhydride levels affect the erosion characteristics of... [Pg.176]

Figure 1 Schematic illustration of an ideal stimuli-modulated polymeric drug delivery system.

Polymeric drug delivery systems, for cancer treatment, 9 82... [Pg.734]

In this study, we demonstrate new pH/temperature-sensitive polymers with transitions resulting from both polymer-polymer and polymer-water interactions and their applications as stimuli-responsive drug carriers [22-23], For this purpose, copolymers of (Ai,Ai-dimethylamino)ethyl methacrylate (DMAEMA) and ethylacrylamide (EAAm) [or acrylamide (AAm)] were prepared and characterized as polymeric drug delivery systems modulated for pulsatile and time release. [Pg.51]

Polymeric Drug Delivery Systems, edited by Glen S. Kwon... [Pg.549]

Another driver for novel polymer research was the increasing complexity of polymeric drug delivery systems. An ideal polymer for these applications should serve the following requirements ... [Pg.347]

Jacob, J.S., et al., Polymeric drug delivery system for hydrophobic drugs, US patent application 20050249799, published on November 10, 2005. [Pg.636]

Weiner, A.L. 1994. Polymeric drug delivery systems for the eye. In Polymeric site-specific pharmacotherapy, ed. A.J. Domb, 315-346. Chichester Wiley. [Pg.521]

M. Hashida and Y. Takakura. Pharmacokinetics in design of polymeric drug delivery systems. J. Control. Release 31 163—171, 1994. [Pg.38]

Polymeric drug delivery system HPLC Precolumn C CH,CN oOmA/PO,. 340 nm Method review [674]... [Pg.215]

Surface Chemical Analysis of Polymeric Drug Delivery Systems by Static Secondary Ion Mass Spectrometry (SSIMS) and SIMS Imaging... [Pg.100]

The interest in the surface chemical characterization of polymeric drug delivery systems is primarily two-fold firstly, the... [Pg.100]

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