4- Diltiazem

Na+ K+ Ga + TTX, DDT, veratridine, scorpion toxins, procaine, Hdocaine quinidine, tolbutamide, diazoxide, glyburide, minoxidil nifedipine, diltiazem, verapamil, moUusc and spider toxins ... [Pg.271]

Patients having high plasma renin activity (PRA) (>8 ng/(mLh)) respond best to an ACE inhibitor or a -adrenoceptor blocker those having low PRA (<1 ng/(mLh)) usually elderly and black, respond best to a calcium channel blocker or a diuretic (184). -Adrenoceptor blockers should not be used in patients who have diabetes, asthma, bradycardia, or peripheral vascular diseases. The thiazide-type diuretics (qv) should be used with caution in patients having diabetes. Likewise, -adrenoceptor blockers should not be combined with verapamil or diltiazem because these dmgs slow the atrioventricular nodal conduction in the heart. Calcium channel blockers are preferred in patients having coronary insufficiency diseases because of the cardioprotective effects of these dmgs. [Pg.132]

Nifedipine, verapamil, and diltiazem are all efficacious in the treatment of mild and moderate hypertension, but nifedipine is more efficacious than diltiazem and verapamil in the control of severe hypertension. Nifedipine does not cause significant reflex tachycardia or orthostatic hypotension. Nifedipine benefits the older and black patients and patients with low PRA. [Pg.142]

Diltiazem inhibits calcium influx via voltage-operated channels and therefore decreases intracellular calcium ion. This decreases smooth muscle tone. Diltiazem dilates both large and small arteries and also inhibits a-adrenoceptor activated calcium influx. It differs from verapamil and nifedipine by its use dependence. In order for the blockade to occur, the channels must be in the activated state. Diltiazem has no significant affinity for calmodulin. The side effects are headache, edema, and dizziness. [Pg.142]

Preparation of calcium antagonist diltiazem, derivative of 2,3-dihydro-4//-l,4-benzothiazepinone 99YGK394. [Pg.235]

The anti anginal agent diltiazem (104) is synthesized starting with opening of the epoxide moiety of with the anion of 2-nitrothiophenol to give 100. This is resolved with cinchoni-... [Pg.198]

Azaclorzine Bepridil Cinepazet Diltiazem Droprenil amine... [Pg.254]

Ethyl chlorimidoacetate Oxyphencyclimine Ethyl chloroacetate Diltiazem HCI Etomidate HCI Piracetam Ticrynafen... [Pg.1633]

Verapamil is a phenylalkylamine which blocks L-type Ca2+ channels in a use-dependent manner. The drug binds to the inactivated state of the channel. Diltiazem is a benzothiazepine derivative with a profile of action most similar to that of verapamil. [Pg.100]

BenzothiazqDines (e.g. Diltiazem) block dihydropyridine-sensitive HVA calcium channels. [Pg.254]

Diltiazem is the only benzothiazepine in clinical use. Its molecular mechanism of action as well as its pharmacological effects closely resemble those of phenylalkylamines. [Pg.298]

Verapamil, diltiazem, amiodarone Diminished renal and nonrenal excretion ... [Pg.327]

Several drugs have been reported to block CNG channels. The most widely used among these drugs is L-cis diltiazem which blocks CNG channels in a voltage-... [Pg.402]

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