Dutasteride 4 Diltiazem

CYP450 Dutasteride may increase in the presence of inhibitors of CYP3A4, such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, and ciprofloxacin. 

Dutasteride (Avodart) [Androgen Hormone Inhibitor/BPH Agent] Uses Symptomatic BPH Action 5a-Reductase inhibitor 4- intracellular androgen levels Dose 0.5 mg PO/d Caution [X, -] Hepatic impair pregnant women should not handle pills Contra Women children Disp Caps SE T Testosterone, T TSH, 4- PSA levels, impotence, 4- libido, gynecomastia Interactions T Effects w/ cimeddine, ciprofloxacin, diltiazem, ketoconazole, ritonavir, verapamil EMS None OD Not expected to produce life-threatening Sxs... 

CALCIUM CHANNEL BLOCKERS DUTASTERIDE Plasma concentrations of dutasteride may t when co-administered with diltiazem or verapamil Uncertain, but postulated that it may be due to inhibition of CYP3A4-mediated metabolism of dutasteride Watch for side-effects of dutasteride... 

Because finasteride and dutasteride are metabolized primarily by CYP3A4, the CYP3A4 inhibitors, such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, and ciprofloxacin, may increase the drugs blood levels and, possibly, cause drug-drug interactions. Clinical drug interaction studies have shown no pharmacokinetic or pharmacodynamic interactions between dutasteride and tamsulosin or terazosin, warfarin, digoxin, and cholestyramine. 

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