Diltiazem controlled polymers

Wargo and Drennen used NIR spectroscopy to monitor the potency and applied polymer solids content of controlled release beads at-line during laboratory- and pilot-scale rotogranulation and coating operations [38]. An aqueous suspension of diltiazem HCl, PVP K29/32, and micronized... 

The effects of massing time on the properties of the granules of hydrophilic polymer-based controlled-release formulations were studied by Timmins et al. (43). The formulations consisted of 30% sodium alginate, 10% HPMC, and 50% diltiazem hydrochloride or verapamil hydrochloride. The increase in massing time resulted in an increase in the mean granule size of the formulations. This could be true for all the matrix controlled release formulations, which contain a high concentration of the hydrophilic polymers. 

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