Diltiazem Digoxin

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

Cardiac drugs Amiodarone, atorvastatin, " diltiazem, " digoxin, disopyramide, lovastatin, " nadolol, pravastatin, propranolol, quinidine,"" timolol, verapamil "... 

Schrager BR, Pina I, Frangi M, A lewhite, Sequeira R, Chahine RA Diltiazem, digoxin interaction Circulation ( 9Zy) 68 (Suppl), III-368... 

Rameis H, Ma metschni D, Ganzinger U. The diltiazem-digoxin interaction. C7m Pharmacol Ther (1984) 36, 183-9. 

Blockers are contraindicated in patients with severe bradycardia (heart rate less than 50 beats per minute) or AV conduction defects in the absence of a pacemaker. (3-Blockers should be used with particular caution in combination with other agents that depress AV conduction (e.g., digoxin, verapamil, and diltiazem) because of increased risk for bradycardia and heart block. Relative contraindications include asthma, bronchospastic disease, severe depression, and peripheral vascular disease. (3,-Selective blockers are preferred in patients with asthma or chronic obstructive pulmonary... 

Numerous drugs ((1-blockers, diltiazem, verapamil, digoxin, and amiodarone) can cause bradyarrhythmias (sinus bradycardia and AV nodal blockade). 

Adenosine 3-Blockers Amiodarone Carbamazepine Chloroquine Digoxin Diltiazem Gatifloxacin... 

Ventricular Rate Control is achieved by inhibiting the proportion of electrical impulses conducted from the atria to the ventricles through the AV node. Therefore, drugs that are effective for ventricular rate control are those that inhibit AV nodal impulse conduction P-blockers, diltiazem, verapamil, and digoxin (Tables 6-5 and 6-6). Amiodarone also inhibits AV nodal conduction, but is not a preferred drug for ventricular rate control in AF due to its unfavorable adverse-effect profile (Table 6-6). 

Which of the following best describes diltiazem s effect on digoxin ... 

The answer is b. (Hardman, pp 816-818.) Digoxin levels rise with concomitant administration of diltiazem by an unknown mechanism that reduces renal clearance... 

Blockers, digoxin, diltiazem, verapamil, tricyclic antidepressants -Blockers Opioids... 

Verapamil additive cardiodepressant activity when combined with a -blocker additive impairment of AV conducton when combined with digoxin. Diltiazem as mentioned for verapamil. 

Verapamil and diltiazem have negative inotropic effects. These calcium channel blockers may be harmful in asymptomatic patients with a low LVEF and in post-MI patients without HF symptoms. Digoxin will not be good to use in patients with low FF, with sinus rhythm and no history of HF symptoms, because the benefits will not exceed the risk. 

Diltiazem [P] Increased plasma digoxin and additive AV conduction effects. 

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