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Foods: Grapefruit juice Diltiazem

Pyrimethamine/sulfadoxine and tetracycline have been shown to increase halofantrine levels, and may therefore increase its toxicity. Diltiazem, erythromycin, ketoconazole, mefloquine, quinine, and quinidine might also increase the toxicity of halofantrine because they have been shown to inhibit its metabolism in vitro. The manufacturer has therefore recommended caution with the concurrent use of potent CYP3A4 inhibitors. Fatty food markedly increases halofantrine levels, consequently it is recommended that halofantrine is taken on an empty stomach. Grapefruit juice has a similar effect Note that halofantrine is no longer widely marketed. [Pg.229]


See other pages where Foods: Grapefruit juice Diltiazem is mentioned: [Pg.99]    [Pg.128]    [Pg.236]    [Pg.272]    [Pg.99]    [Pg.99]   
See also in sourсe #XX -- [ Pg.869 ]




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Diltiazem

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