Diltiazem Dopamine

Higashidate, S. Imai, K. Prados, P Adachi-Akahane, S. Nagao, T. Relations between blood pressure and plasma norepinephrine concentrations after administration of diltiazem to rats HPLC-perox-yoxalate chemiluminescence determination on an individual basis. Biomed.Chromatogr, 1994, 8, 19-21 [plasma extracted diltiazem, dopamine, epinephrine, norepinephrine rat chemiluminescence detection SPE]... 

Tokuyama, S. and Ho, I.K. Effects of diltiazem, a Ca2+ channel blocker, on naloxone-precipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats, Psychopharmacol. 1996, 125, 135-140. 

Frusemide is physically incompatible with diltiazem hydrochloride, dobutamine hydrochloride, dopamine hydrochloride, labetalol hydrochloride, midazolam hydrochloride, milrinone lactate, nicardipine hydrochloride, parenteral nutrient solutions, cisatracurium besylate, and vecuronium bromide. 

A 15-year-old woman intentionally took 10 modified-release tablets of diltiazem 200 mg. She developed hypertension, oliguria, pulmonary edema, and respiratory distress syndrome, and required mechanical ventilation for 3 days, besides intravenous calcium, dopamine, and noradrenaline. After 5 days in an intensive care unit, she was transferred to a psychiatric hospital in good physical condition (22). 

A 38-year-old white man with a history of coronary artery disease, myocardial infarction, coronary artery by-pass, alcoholism, and depression took a combined massive overdose of diltiazem and atenolol (24). He underwent cardiopulmonary resuscitation because of cardiac arrest bradycardia, hypotension, and oliguria followed and were resistant to intravenous pacing and multiple pharmacological interventions, including intravenous fluids, calcium, dopamine, dobutamine, adrenaline, prenalterol, and glucagon. Adequate mean arterial pressure and urine output were restored only after the addition of phenylephrine and transvenous pacing. He survived despite myocardial infarction and pneumonia. 

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