Digitalis

Inspection of any textbook of pharmacognosy, pharmacology or natural product chemistry in the middle of the 20th century would show a large number 

3 20th and 21st Century Drugs/Leads from Nature 

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Composed of digitalose, glucose and digi-taligenin. Its action is that of digitalis. 

Gain and phase are digitaly controlled and a very good linearity. 

Digestalin Digesto2yme Digisidin Digital cameras Digitalis... 

Lldoc ine. Lidocaine hydrochloride, an anilide, was originally introduced as a local anesthetic in 1943 and found to be a potent antiarrhythmic in 1960. The compound is a reverse amide of procainamide. Lidocaine is generally considered to be the dmg of choice in the treatment of ventricular arrhythmias and those originating from digitalis glycoside toxicity (1,2,15—17). 

Phenytoin. Phenytoin sodium is sodium diphenylhydantoin [630-93-3] which is stmcturally related to the barbiturates. It was originally introduced as an anticonvulsant (18) (see Hypnotics, sedatives, and anticonvulsants) and later found to have antiarrhythmic properties (19), although not approved by the PDA for any arrhythmic indications. Phenytoin is effective in the treatment of ventricular arrhythmias associated with acute MI and with digitalis toxicity (20). It is not very effective in treatment of supraventricular arrhythmias (20). 

Dlgltoxin. Digitoxin is a cardiac glycoside obtained from Digitalis purpurea. Digitoxin is indicated in the treatment of atrial flutter, atrial fibrillation, and supraventricular tachycardia. Its electrophysiologic and adverse effects are similar to those described for digoxin (87). 

Glandular products, drugs of vegetable origin, such as quinine, strychnine and brucine, emetine, and digitalis glycosides ... 

Digitalis glycosides Apply the sample solution as a band, then cover the layer, apart from the application zone, with a glass plate and place it in an ammonia chamber for 24 to 48 h, remove excess ammoma and chromatograph Acetyl groups are split off [37]... 

Digitalis glycosides Apply sample solution as band and then luizyme solution over it if necessary, moisten the application zone with water. Cover the layer, except for the application zone, with a glass plate and incubate at 39 °C for 2 to 5 h. [37]... 

Liquid paraffin digitalis glycosides stabilization and enhancement 30% in chloroform [242]... 

Fig. 1 Fluorescence scan of a mixture of digitalis glycosides. Digoxin (DG3), digoxigenin bis-digitoxoside (DGj), digoxigenin mono-digitoxoside (DGi), digoxigenin (DG).

The digitalis glycosides yielded blue fluorescent zones in long- wavelength UV light (A = 365 nm) (Fig. 1). 

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