Digitalis glycosides interaction

Methimazole (Tapazole) [Antithyroid Agent] Uses Hyperthy-roidism, thyrotoxicosis, pr for thyroid surgery or radiation Action Blocks T3 T4 formation Dose Adults. Initial 15-60 mg/d PO tid Maint 5-15 mg PO daily Peds. Initial 0.4-0.7 mg/kg/24 h PO tid Maint V h- U h of initial dose PO daily w/ food Caution [D, +/-] Contra Breast-feeding Disp Tabs SE GI upset, dizziness, blood dyscrasias Interactions t Effects OF digitalis glycosides, metoprolol, propranolol X effects OF anticoagulants, theophylline X effects W/ amiodarone EMS None OD May cause N/V, HA, abd pain, fever, and pale skin symptomatic and supportive... 

Drug Interactions Antineoplastlc agents Corticosteroids and corticotropin Cyclosporine-A Digitalis glycosides Flucytosine Imidazoles Leukocyte transfusions Nephrotoxic medications Skeletal muscle relaxants Zidovudine... 

Pedersen KE. Digoxin interactions. The influence of quinidine and verapamil on the pharmacokinetics and receptor binding of digitalis glycosides. Acta Med Scand Suppl 1985 697 1-40. 

Drugs interacting with digoxin and other digitalis glycosides. 

Digitalis glycoside Neither citalopram nor fluvoxamine appear to interact with digoxin, but an isolated report describes increased serum digoxin levels attributed to the use of fluoxetine. 

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