Digitalis purpurea

Dlgltoxin. Digitoxin is a cardiac glycoside obtained from Digitalis purpurea. Digitoxin is indicated in the treatment of atrial flutter, atrial fibrillation, and supraventricular tachycardia. Its electrophysiologic and adverse effects are similar to those described for digoxin (87). 

Digitoxigenin is a heart stimulant obtained from the purple foxglove Digitalis purpurea and used in the treatment of heart disease. Draw the three-dimensional conformation of digitoxigenin, and identify the two —OH groups as axial or equatorial. 

Theory The assay of cholesterol is solely based on the fact that practically all 3 (3-hydroxysterols e.g., cholesterol, readily produces an insoluble molecular addition complex with pure digitonin (1 1)—a steroidal saponin isolated from either Digitalis purpurea or Digitalis lanata. The complex thus obtained is crystalline in nature, fairly stable and possesses very low solubilities. 

Some of the most well-known cardenolides include digitoxin from Digitalis purpurea (foxglove), convallarin from Convallaria (lily-of-the-valley), ouabain from Strophanthus and Acocanthera, many digitoxin-like cardenolides from... 

Digitalis glycosides Digitalis purpurea L., D. Cardiotonic glycosides... 

Glycosides isolated from leaves of various types of foxglove Digitalis lanta. Digitalis purpurea, and strophanthus Strophantus kombe, and also a number of other plants (hhes, periploca, oleander, hellebore, erysimum, jute, Irish ballon), which exhibit a direct effect on the myocardium and which strengthen its contractions. 

That which is usually extracted from both types of Digitalis is made up of already partially hydrolyzed glycosides. Purpureaglycoside A and B are natural glycosides contained in Digitalis purpurea that are broken down by enzymes into digitoxin and glucose, or... 

Digoxin Steroid Increases heart muscle contraction Digitalis purpurea (purple foxglove)... 

Cardiac steroids, or cardenoUdes, are steroid glycosides. Their effect has been known since the time of the ancient Egyptians. In more recent times, the foxglove (Digitalis purpurea) and its effect were described in 1785 by William Withering, who knew of its use in folk medicine. 

Digitalis Digitalis purpurea, Digitalis lanata) Digoxin etc. 

As part of our investigations (1,2) of the psychotropic Mexican labiate. Salvia divinorum Epling Jativa-M., we report the presence of loliolide (1), previously isolated from Lolium perenne (3), Gramineae, Digitalis purpurea L. (4), Scrophulariaceae, and several other species (5). The compound has recently been described to be a potent ant-repellent (8). 

The enzyme catalyzing the transfer of D-apiose from UDP-apiose to 4, 5-dihydroxyflavon-7-yl /3-D-glucopyranoside is commonly called apiin synthetase.7 Activity is measured by the formation of [14C]apiin from UDP-[U-14C]apiose. Apiin synthetase can be measured by the rapid separation and isolation, by poly(ethylenimine)-paper chromatography, of a product of the reaction, namely, [14C] apiin, from UDP-D-[U-14C]xylose and degradation products of UDP-[U-14C]apiose.31 There are reports of the isolation and purification of apiin synthetase from parsley leaves,31 from cell-suspension cultures of parsley,121 and from foxglove (Digitalis purpurea).31 Apiin synthetase isolated from parsley does not require metal ions, NAD+, or other cofactors, and is soluble. It is inhibited by several heavy metals, but not by tetra-N-... 

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