Digitalis glycosides Digitoxin

Also called digitalis glycoside, digitoxin, digoxin... 

Dlgltoxin. Digitoxin is a cardiac glycoside obtained from Digitalis purpurea. Digitoxin is indicated in the treatment of atrial flutter, atrial fibrillation, and supraventricular tachycardia. Its electrophysiologic and adverse effects are similar to those described for digoxin (87). 

Digitalis glycosides [NE] Decreased gastrointestinal absorption of digitoxin (possibly also digoxin). 

Figure 6.8b compares the three major digitalis glycosides that are (or have been) used clinically. The stmcture of digitoxin is depicted completely, with both the steroid-like aglycone moiety and the three residues of digitose, which is a hexose that lacks two hydroxyl groups. These are represented by R in the two other stmctures and actually not... 

Digitoxin is the most potent of the digitalis glycosides besides being the most cumulative in... 

Phenytoin has a stabilising effect on the myocardial cells so that the toxic threshold of digoxin at which arrhythmias occur is raised. However, the bradycardic effects of the digitalis glycoside are not opposed and the lethal dose is unaltered, so that the cardiac arrest reported would appear to be the result of excessive bradycardia. It seems possible that the fall in plasma digitoxin levels may be due to a phenytoin-induced increase in the metabolism of the digitoxin by the liver. ... 

Colestipol appears not to interfere with the absorption of either digoxin or digitoxin if it is given at least 1.5 hours after the digitalis glycoside. 

---