Digitalis glycosides Lanatoside

Common Name Celanidum Glycoside C from Digitalis lanata Lanatoside C... 

Isol. by mild acid hydrolysis from the glycosides lanatoside A, B and C (from Digitalis species), Erysimoside (from Erysimum perofskianum) and from the glycosides of Isoplexis isabelliana and from Isoplexis canariensis. 

Digitalis purpureae folium (2) is characterized by the major zone of purpurea glycoside A with a slightly lower R, value than lanatoside C (Tl). Purpurea glycoside B is found as a minor zone directly below purpurea glycoside A, followed by a cardenolide zone at R, 0.2. 

This was also confirmed by the correlation study of cardenolide contents in Digitalis lamta plants between ELISA and HPLC. The cardenolide contents in leaves of D. lanata cultivated in the field or hydroponic facilities were quantitatively analyzed by both ELISA and HPLC (Fig. 8). The content of digoxin equivalents in the leaves by ELISA correlated well to the total content of digoxin, deslanoside and lanatoside C as analyzed by HPLC. This indicates that the digoxin equivalents obtained by ELISA represent the total amount of digoxigenin glycosides present in the crude extracts of D. lanata. 

The cardiac glycosides found in plants and animals and the bufadienohde esters, hke bufotahn, have a bitter taste and a high toxicity, properties which may repel potential predators (E 5.1 and E 5.5.3). Several cardiac glycosides, e.g., digitoxin, digoxin, and lanatoside C made by Digitalis lanata (Table 39), are used as cardiotonics in medicine (F 2). 

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