Diffuse lung disease

Hallee TJ. 1969. Diffuse lung disease caused by inhalation of mercury vapor. Am Rev Respir Dis 99 430-436. 

Source Reprinted from Azuma et al. [89] with permission from the Sarcoidosis Vasculitis and Diffuse Lung Disease. 

Beigelman-Aubry C, Hill C, Guibal A, Savatovsky J, Grenier PA (2005) Multi-detector row CT and postprocessing techniques in the assessment of diffuse lung disease. Radiographics 25(6) 1639-1652... 

Colby TV, Swensen SJ. Anatomic distribution and histopathologic patterns in diffuse lung disease correlation with HRCT. J Thorac Imaging 1996 ll(l) l-26. Kobayashi H, Matsuoka R, Kitamura S, et al. Sjogren s syndrome with multiple bullae and pulmonary nodular amyloidosis. Chest 1988 94(2) 438-440. 

Mohr LC. Hypersensitivity pneumonitis. Curr Opin Pulm Med 2004 10 401-411. Fukuoka J, Franks TJ, Colby TV, et al. Peribronchiolar metaplasia a common histologic lesion in diffuse lung disease and a rare cause of interstitial lung disease clinicopathologic features of 15 cases. Am J Surg Pathol 2005 29 948-954. 

This chapter will discuss the several agents that have been proposed for potential therapy for various diffuse lung diseases. Table 1 lists the agents to be discussed in general classes. Examples of the use of these drugs for specific ILDs are cited in the table. In most cases, the role of these drugs remains unclear. In fact, the value of any treatment for IFF is controversial (14,15). 

Coates EO Jr, Watson JHL Diffuse interstitial lung disease in tungsten-carbide workers. Ann Intern Med 75(5) 709-716, 1971... 

Scanning electron microscopy (SEM) in concert with x-ray energy spectrometry (XES) has been used to detect silver in pulmonary, lacrimal sac, and skin tissues of individuals with diffuse interstitial lung disease, chronic dacryocystitis, and skin disorders, respectively (Brody et al. 1978 Loeffler and Lee 1987 Tanita et al. 1985). Brody et al. (1978) observed particles of preselected lesions of human pulmonary tissue magnified to 300x by SEM, and the silver content was analyzed by XES. The authors noted that SEM and XES techniques permit a rapid and conclusive determination of silver, silver compounds, and complexes in tissue lesions. 

Decreased phagocytosis leading to interaction of the particles with the epithelium, resulting in the development of conditions such as chronic diffuse interstitial fibronodular lung disease... 

In 25 patients, three had proven interstitial pneumonitis and KL-6 serum concentrations of 414, 848, and 1217 U/ ml in contrast, all of the other 22 patients had normal CT scans and normal KL-6 concentrations (under 500 U/ml) (82). In the same study the limitations of carbon monoxide diffusing capacity in the diagnosis of amiodarone-induced lung disease (SEDA-15, 168) were again demonstrated. 

Pesenti S, Lauque D, Daste G, Boulay V, Pujazon MC, Carles P. Diffuse infiltrative lung disease associated with flecainide. Report of two cases. Respiration 2002 69(2) 182-5. 

The diffusing capacity will be reduced in aU clinical situations in which there is impairment of gas transfer from the alveoli to capillary blood. Common conditions that reduce the Dlco include lung resection, emphysema (loss of functioning alveolar-capillary units), and interstitial lung disease (thickening of the alveolar-capiUary membrane). Normal PFTs with a reduced Dlco should suggest the possibility of pulmonary vascular disease (e.g., pulmonary embolus) but also can be seen with anemia, early interstitial lung disease, and mUd Pneumocystis carinii (PCP) infection in AIDS patients. 

Late pulmonary complications cover a wide spectrum of disorders and include both obstructive and restrictive lung diseases. Included in these disorders are bronchiolitis obliterans with or without organizing pneumonia, diffuse alveolar damage, and lymphocytic interstitial pneumonia. 9,80 xjjgj- py consists of steroids, which are... 

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