0,0-Diethyl 0- -4-pyrimidinyl

The cyclization of educts with a C-C-C—N pyrimidine structure is similar to the second step of the Gould-Jacobs reaction.194 The reaction of an appropriately substituted pyrimidin-4-amine with diethyl (ethoxymethylene)malonate affords the requisite diethyl [(pyrimidinyl-amino)methylene]malonate. The thermal cyclization of this intermediate, an acylation of the pyrimidine nucleus by one of the ester functions to give ethyl 5-oxopyrido[2,3-t/]pyrimidine-6-carboxylate 1, is effected by heating to 250-320 °C, preferably in mineral oil,195 Dowtherm,196 or diphenyl ether.197 201... [Pg.114]

Chemical Designations - Synonyms 0,0-Diethyl 0-(-Isopropyl-6-Methyl-4-Pyrimidinyl)... [Pg.109]

Diazinon (phosphorothioic acid 0,0-diethyl 0-(6-mcthyl-2-(l-mcthylcthyl)-4-pyrimidinyl) ester) is an organophosphorus compound with an anticholinesterase mode of action. It is used extensively to control hies, lice, insect pests of ornamental plants and food crops, as well as nematodes and soil insects in lawns and croplands. Diazinon degrades rapidly in the environment, with half-time persistence usually less than 14 days. But under conditions of low temperature, low moisture, high alkalinity, and lack of suitable microbial degraders, diazinon may remain biologically active in soils for 6 months or longer. [Pg.980]

Chloropyrimidine was coupled with diethyl (3-pyridyl)borane in the presence of Pd(Ph3P)4, Bt NBr, and KOH to afford 3-(2 -pyrimidinyl)pyridine [23]. Likewise, the Suzuki coupling of 2-bromopyrimidine with diethyl (4-pyridyl)borane (47) led to 4-(2 -pyrimidinyl)pyridine (48) in 50% yield, whereas 2-chloropyrimidine produced 48 in only 20% yield under the same conditions [24], Diethyl (4-pyridyl)borane (47), on the other hand, was readily accessible from sequential treatment of 4-bromopyridine with n-BuLi and diethylmethoxyborane. [Pg.383]

Snyder et al. [94] compared supercritical extraction with classical sonication and Soxhlet extraction for the extraction of selected organophosphorus insecticides from soil. Samples extracted with supercritical carbon dioxide modified with 3% methanol at 350atm and 50°C gave a =85% recovery of Diazinon (diethyl-2-isopropyl-6-methyl-4-pyrimidinyl phosphorothiodate or 0,0 diethyl-0-(2-isopropyl-6-methyl-4-pyrimidyl) phosphorothioate). Ronnel (or Fenchlorphos) 0,0-dimethyl-0-2,4,5 trichlorophenol phosphorothiodate), Parathion ethyl (diethyl-p-nitrophenyl (phosphorothioate), Tetrachlorovinphos (trans,-2-chloro-l-(2,4,5 trichlorophenyl) vinyl (chlorophenyl-O-methylphenyl phosphorothioate) and Methiadathion. Supercritical fluid extraction with methanol modified carbon dioxide has been applied to the determination of organophosphorus insecticides in soil [260]. [Pg.234]

Diazinon (diethyl-2-isopropyl-6-methyl-4-pyrimidinyl phosphorothioate or 0,0-diethyl-o-(2-isopropyl-6-methyl-4-pyrimidyl phosphorothioate)... [Pg.255]

Diaminopyrimidines were reacted with EMME in boiling ethanol for 30 min (68AF1214) or for 180 min (70CPB1385), or at 135-165°C for 20-60 min (72JOC3980), to afford N-(6-amino-4-pyrimidinyl)amino-methylenemalonates (182) in 20-79% yields. Diethyl 7V-(4,6-diamino-5-... [Pg.56]

Plant Diaziuou was rapidly absorbed by and translocated in rice plants. Metabolites identified in both rice plants and a paddy soil were 2-isopropyl-4-methyl-6-hydroxypyrimidine (hydrolysis product), 2-(l -hydroxy-l -methyl)ethyl-4-methyl-6-hydroxypyrimidine, and other polar compounds (Laanio et al, 1972). Oxidizes in plants to diazoxon (Laanio et al., 1972 Ralls et al, 1966 Wolfe et al., 1976) although 2-isopropyl-4-methylpyrimidin-6-ol was identified in bean plants (Kansouh and Hopkins, 1968) and as a hydrolysis product in soil (Somasundaram et al., 1991) and water (Suffet et al., 1967). Five d after spraying, pyrimidine ring-labeled C-diazinon was oxidized to oxodiazinon which then hydrolyzed to 2-isopropyl-4-methylpyrimidin-6-ol which, in turn, was further metabolized to carbon dioxide (Ralls et al, 1966). Diazinon was transformed in field-sprayed kale plants to hydroxydiazinon 0,0-diethyl-0-[2-(2 -hydroxy-2 -propyl)-4-methyl-6-pyrimidinyl] phosphorothioate which was not previously reported (Pardue et al., 1970). [Pg.1569]

Di-(2-Ethylhexyl)Acid Phosphate Di-(2 Ethylhexyl)Adipate Di-(2-Ethylhexyl)Phosphate Di-(2-Ediylhexyl)Phosphoric Acid Di(2-Ethylhexyl) Phthalate Di-(2-Ethylhexyl)Sulfosuccinate Sodium Salt 0,0-Diethyl 0-(2-Isopropyl-6-Methyl -4-Pyrimidinyl)Phosphorothioate 0,0-Diethyl-0-(2-Isopropyl-6-Methyl-4-Pyrimidinyl) Phosphorothioate... [Pg.42]

Diethyl-0-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothionate 0,0-diethyl-0-[6-methyl-2-(1 -methylethyl)-4-pyrimidinyl] phosphorothioate others... [Pg.125]

Diazinon is the Ciba-Geigy Corporation trademark name for the active ingredient 0,0-diethyl-0-(2-[l-methylethyl]-4-methyl-6-pyrimidinyl) phosphorothioate. This insecticide is produced commercially by reacting 2-isopropyl-4-hydroxy-6-methylpyrimidine and 0,0-diethyl phosphorochloridothioate (HSDB... [Pg.127]

Harris LW, JH Fleisher, Innerebner, et al. 1969. The effects of atropine-oxime therapy on cholinesterase activity and the survival of animals poisoned with diethyl-0-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate. Toxicol Appl Pharmacol 15 216-226. [Pg.196]

Chemical Name 0,0-diethyl 0-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate 0,0-diethyl-0-(2-isopropyl-6-methyl 4-pyrimidinyl) phosphorothioate 0,0-diethyl 2-isopropyl-4-methylpyrimidinyl-6-thiophosphate Uses nonsystemic insecticide to control flies, aphids and spider mites in soil, fruit, vegetables and ornamentals also... [Pg.616]

A novel device was designed to estimate the dislodgeability of dust-associated pesticide residues by skin contact (Edwards and Lioy, 1999). Called the EL Sampler , the device consists of a spring-loaded assembly that permits the sampling medium to be pressed lightly (12g/cm or 1160 Pa) onto the surface to be monitored. A 10-cm x 15-cm Empore C-18 extraction membrane was used for the sampling medium. The material was chosen after controlled experiments on particle adhesion showed it to pick up the same distribution of test dust particle sizes as the human hand. In studies in which the EL sampler was pressed onto polyethylene surfaces coated with house dust and then sprayed with a solution of pesticides in 2-propanol, the device was found to collect 35%, 31 %, 32% and 18 %, respectively, of chlorpyrifos, diazinon (0,0-diethyl 0-[6-methyl-2-(l-methylethyl)-4-pyrimidinyl] phosphorothioate), malathion and atrazine (6-chloro-A -ethyl-A -isopropyl-l,3,5-triazine-2,4-diamine). Parallel studies with human hand presses (full hand at 6.8 kg = ca. 6900 Pa) yielded collection efficiencies of 42 %, 29 %, 43 % and 21 %, respectively. [Pg.102]

DJJ393 CAS 32522-68-2 HR 3 0,0-DIETHYL S-(2-(ETHYLTHIO)-6-METHYL-4-PYRIMIDINYL) PHOSPHORODITHIOATE... [Pg.491]

DIETHYL/ MIN0)-6-METHYL-4-PYRIMIDINYL)-0,0-DIMETHYL PHOSPHOROTHIOATE see DIN800 7-DIETHYLAMINO-5-METHYL-s-TRIAZOLO(l,5-a)PYRIMIDINE see DI0200... [Pg.1625]

DIETHYL-0-6-METHYL-2-IS0PR0PYL-4-PYRIMIDINYL PHOSPHOROTHIOATE see DCM750 DIETHYLMETHYL METHANE see MNI500 1,1-DIETHYL-3-METHYL-3-NITROSOUREA see DJP600... [Pg.1628]

Diaznon 0,0-Diethyl 0-(-Isopropyl-6-Methyl-4-Pyrimidinyl) 0,0-Diethyl O-2-Isopropyl-4-Methyl-6-Pyrimidyl Thiophosphate Diethyl 2-Isopro-pyl-4-Methyl-6-Pyrimidyl Thionophosphate Alpha-Tox Saralex... [Pg.241]

On small fires, use dry chemical powder (such as Purple-K-Powder), alcohol-resistant foam, or COj extinguishers. PHOSPHORIC ACID, O.O-DIETHYL-O-6-METHYL-2-(l-METHYLETHYL)-4-PYRIMIDINYL ESTER (333-41-5) C.jHj.NjOjPS Commercial products containing hydrocarbon carriers acetone, ethanol, xylene can form explosive mixture with air [flashpoint 82 to 105°F/28 to 41°C]. A weak base. Hydrolyzes slowly in water and dilute acid ll With excess water this conqjound produces diethylthiophosphoric acid and 2-isopropyl-4-methyl-6-pyrimidol. With insufficient water or contact with strong alkalis or acids, this compound produces highly toxic tetraethyl monothiopyrophosphate. Contact with oxidizers may cause the release of toxic phosphoms oxides. Contact with strong... [Pg.864]

PHOSPHORIC ACID, 0,O-DIETHYL-O-6-METHYL-2-(l-METHYLETHYL)-4-PYRIMIDINYL ESTER (333-41-5) A weak base. Hydrolyzes slowly in water and dilute... [Pg.977]

Phosphorothioic acid 0- 2-(dimethylamino)-6-methyl-4-pyrimidinyl] 0,0-diethyl ester. [Pg.532]

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