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Dialysis solutions formulation

Perhaps the most important medical use of dialysis is in artificial kidney machines, where hemodialysis is used to cleanse the blood of patients whose kidneys have malfunctioned. Blood is diverted from the body and pumped through a cellophane dialysis tube suspended in a solution formulated to contain many of the same components as blood plasma. These substances—glucose, NaCl, NaHC03, and KC1—have the same concentrations in the dialysis solution as they do in blood, so that they have no net passage through the cellophane membrane. [Pg.461]

Formulation Preparation Irrigations Dialysis solutions Peritoneal dialysis Haemofiltration... [Pg.301]

NIR has been applied to prediction of the concentrations of glucose and lactic acid in peritoneal dialysis solution, which is a medical product and not a fermentation broth (22). The peritoneal dialysis solution is introduced into the peritoneal cavity of renal failure patients, and waste materials in the blood are dialyzed into the solution through the peritoneum. MLR was used to obtain calibration equations relating the NIR spectral data and the glucose and lactic acid concentrations of a calibration sample set obtained by enzymatic methods. A calibration equation for glucose in peritoneal dialysis solution was formulated with second-derivative NIR spectral data at 2270 nm, and the values of r and SEC were 0.996 and 2.03 g-l respectively. A calibration equation for lactic acid in peritoneal dialysis solution was formulated with the second-derivative NIR spectral data at 1688 and 1268 nm, and the values of R and SEC were 0.997 and 0.178 g-C respectively. In the validation results of the calibration equations, excellent agreement between the results of the enzymatic method and the NIR method was also observed for these constituents. The values of r for glucose and lactic acid in the peritoneal dialysis solution were 0.996 and 0.996, respectively. [Pg.352]

Dialysis fluids are solutions of electrolytes formulated in concentrations similar to those of extracellular fluid or plasma. They contain, or may contain ... [Pg.1094]

Among the best-known nonderivatizing solvent systems is a combination between copper, alkali, and ammonia termed Schweizer s reagent. Solutions of cuprammonium hydroxide have been used for both analytical and industrial cellulose dissolution. Regenerated fibers with silk-like appearance and dialysis membrane have been (and partially continue to be) industrial products on the basis of cellulose dissolution in cuprammonium hydroxide. The success of this solvent is based on the ability of copper and ammonia to complex with the glycol functionality of cellulose as shown inO Fig. 11. Because of the potential side reactions (oxidation and crosslinking, Norman compound formation), alternatives to both ammonia as well as copper have been developed. Cuen and cadoxen are related formulations based on the use of ethylene diamine and cadmium, respectively. The various combinations of alkali, ammonia. [Pg.1485]

Electrolytic solutions used for extra-renal infusion and dialysis contain metal chlorides of Na, K, Ca and Mg salts at concentrations that are critical for effective treatment. These solutions also contain dextrose, citrate and lactate additives as part of this special formulation. The analysis for these metals must be precise and accurate and this can be achieved with ICP-OES using yttrium or scandium as internal standard to correct for matrix affects. The method of standard addition may also be used with similar success but is a more tedious method. The ability to dilute the sample several fold due to the high concentrations of metals reduces/eliminates the effect of EIE (easily ionised elements) caused by other elements in the same solution. The dilution and the ease of detection and corrections with an internal standard using the multi-element capability make this an excellent method. [Pg.235]

The use of calcined clay as a filler has shown to lead to the release of soluble aluminium from rubber closures into the parenteral solution (Milano et al., 1982). Various techniques for the determination of soluble aluminium in rubber closures have been proposed (Mondimore and Moore, 1983). There has been concern about aluminium since the 1970s, when a link was identified between high aluminium levels in tap water used for renal dialysis equipment and accumulation of the element in the brain. The injection of parenteral solutions into the body effectively bypasses the normal defence mechanisms and under these circumstances may present a challenge to the normal metabolic processes (Massey and Taylor, 1989). In response to these challenges, suppliers have developed rubber formulations that are essentially free from materials containing aluminium compounds. [Pg.352]

Nonviral formulations are generally more efficient and more toxic as the polymer-to-nucleic acid ratio is increased (higher N/P ratios), suggesting a role of free uncomplexed polymer in the solution in efficient delivery and toxicity. A recent report has shown that polyplexes of DNA and PEI contain an average of 3.5 plasmids (5800 base pairs) and 30 PEI (25 kDa) molecules when prepared at N/P ratios of 6 and 10, assuming that the DNA is completely complexed [267]. Based on these calculations, there is 86% of free PEI in the complex mixture [267,268]. Purification of the PEl/DNA complexes by dialysis has shown a reduction of toxcicity however, it also reduced transfection efficiency [269]. Efficient gene transfer was restored when free PEI was added to the mixture [269]. [Pg.1041]

Membranes used in microfiltration, reverse osmosis, dialysis, and gas separation are usually prepared by the wet-extrusion process, since it can be used to produce almost every membrane morphology. In the process, homogeneous solutions of the polymers are made in solvent and nonsolvent mixtures, while phase inversion is achieved by any of the several processes, such as solvent evaporation, exposure to excess nonsolvent, and thermal gelation. In most formulations, polymer solutions of 15-40 wt% concentration are cast or spun and subsequently coagulated in a bath containing a nonsolvent (usually water). [Pg.649]

In the literature, two methods are often used to prepare cationic polymer-DNA complexes. The first method is direct mixing, which is generally used to formulate traditional polyplexes. According to this method, aqueous suspensions of cationic polymers and plasmid DNA are mixed rapidly. " The other method is the detergent dialysis method, which was initially used for preparing relatively stable cationic lipid-DNA particles. For this method, a DNA and cationic lipid mixture is dissolved in a detergent solution, which is followed by a subsequent dialysis process to remove the detergent. [Pg.281]

Liquids. Liquid enzyme formulations usually contain a significant amount of stabilizing agents, such as carbohydrates, polyols and inactive (filler) proteins. In addition, side-products from the fermentation may be present. In general, they tend to stabilise enzymes and thus their removal (e.g., by dialysis) is not recommended. The same apphes to dilution, as concentrated protein solutions are usually more stable. Liquid formulations should be stored in the cold (0 to +4°C), but avoid freezing If long-term storage is required, two options are possible (if in doubt, test both methods on a sample first and check for any loss of activity) ... [Pg.399]

Because irrigations are used in or on body areas that are usually sterile or have a low degree of contaminatiOTi, there are strict requirements for their production and quality control. In this chapter the use, the design of formulation and preparation method as well as the on site preparation of irrigations will be discussed. With regard to solutions for various types of dialysis, the use of concentrates, the water quality and the requirements for bacterial endotoxins are fully discussed. [Pg.301]


See other pages where Dialysis solutions formulation is mentioned: [Pg.305]    [Pg.515]    [Pg.398]    [Pg.37]    [Pg.856]    [Pg.171]    [Pg.291]    [Pg.230]    [Pg.146]    [Pg.346]    [Pg.625]    [Pg.856]    [Pg.264]    [Pg.418]    [Pg.419]    [Pg.625]    [Pg.6]    [Pg.417]    [Pg.32]    [Pg.856]    [Pg.168]    [Pg.191]   
See also in sourсe #XX -- [ Pg.304 ]




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