Detailed assessment

If the maximum values of (DCFRR) and (NPV) are not acceptable to the company, the project should promptly be rejected. If the minimum values or (DCFRR) and (NPV) are acceptable, a detailed assessment should be made. If the maximum values of (DCFRR) and (NPV) are acceptable but the minimum values are not, the feasibility study should be continued. 

The official report sums up the lessons of the fire by saying that it might have been prevented or its severity greatly reduced if a more detailed assessment of the inherent hazards and risks of the plant had been carried out by the company beforehand and if adequate records had been kept to build up a history on which an inspection and replacement program could have been based. 

Lewis, D. J. 1981. Estimating damage from aerial explosion type incidents—Problems with a detailed assessment and an approximate method. Euromech 139. Aberystwyth (UK). 

Having agreed on PSM goals and objectives, your next step is to conduct a more detailed assessment of the present status of PSM activities within your company, to form the basis for your implementation plan. This baseline assessment works against both the model you have selected for PSM and the characteristics that describe a sound management system, such as those described by CCPS. 

The main output from this stage is a detailed assessment of the human error problem areas. If possible this should include quantitative data on the incidence of errors and the significance of their consequences. This will provide a valuable baseline against which to evaluate the success of the error management program. 

Experience indicates that in a typical company there will be considerable overlap between and within the PSM and ESH and quality management systems. Your work to secure support (Chapter 2) will have already demonstrated many of these overlaps. The detailed assessment of the existing management systems described in this chapter will provide a comprehensive understanding of the overlaps. 

The Olefins and Additives divisions were subjected to a detailed assessment... 

Some industries are interested only in certain aspects of soil assessment and do not require a detailed assessment. 

Provide a detailed assessment of the technology of CVD and its relation to the production of coatings, fibers, powders, and monolithic shapes. 

To obtain an increased intrinsic capacity to transgress biological membranes, a number of different modifications have been introduced to PNA. These modifications include conjugation of PNA to Hpophilic moieties [51, 97, 98], conjugation of PNA to certain so-caUed ceU-penetrating peptides [49, 55, 56, 66, 99-102] and conjugation to different moieties, which are supposed to be internahzed by specific cellular receptors [48, 103-105]. The work on cellular dehvery of PNA is, like the related work on ex vivo and in vivo effects of PNA, very difficult to summarize conclusively. First of all, the pronounced diversity of the reporter systems employed makes it impossible to directly compare the studies. Secondly, the widespread use of fluorescence studies in spite of the many inherent pitfalls of this technique makes it sometimes difficult to judge even qualitatively whether a presented result actually indicates cellular uptake. We have recently published a comprehensive review on cellular dehvery of PNA [82], with a more detailed assessment of the PNA dehvery hterature. 

When choosing a particular solvent for a specific application a wide range of factors should be considered, including some not directly related to the specific application. Obviously cost, efficacy and safety need to be considered first, and these will generally rule out some options. Following this a more detailed assessment of additional factors should be carried out, ideally including ... 

The comprehensive and detailed assessment of the risks required for a safety-case can only be satisfactorily carried out for major installations with the aid of computer software. Suites of programmes for quantitative risk analysis have been developed over the past decade by consulting firms specializing in safety and environmental protection. Typical of the software available is the SAFETI (Suite for Assessment of Flammability Explosion and Toxic Impact) suite of programs developed by DNV Technica Ltd. These programs were initially developed for the authorities in the Netherlands, as a response to the Seveso Directives of the EU (which requires the development of safety cases and hazard reviews). The programs have subsequently been developed further and extended, and are widely used in the preparation of safety cases see Pitblado el al. (1990). 

There are very few cases of active stars with known coronal and photospheric abundances. Therefore a detailed assessment of the presence of FIP or MAD biases can only be done in a small number of stars. More work is clearly needed. 

Abstract The ability to clone, express, and electrophysiologically measure currents carried by voltage-gated ion channels has allowed a detailed assessment of the action of pyrethroids on various target proteins. 

The assessment and quantification of the remaining reserves and resources of fossil fuels is a very complex and broad field, characterised by a lack of internationally harmonised definitions and standards, great data uncertainties and discrepancies and, consequently, the potential danger of data abuse for political purposes. Within the scope of this publication, only an overview of the range of the currently available estimates of fossil resources is provided and the focus is rather on the general discussion of potential sources of uncertainty, than on a detailed assessment of the different methodological and statistical approaches and discrepancies at country or even field level. 

Phase II studies encompass a detailed assessment of the compound s safety and efficacy in a larger patient population (a few-to-several hundreds of patients). It is important that any formulation selected for these studies must be based on sound biopharmaceutical and pharmaceutical technology principles. Phase III clinical studies, also referred to as pivotal studies, involve several thousands of patients in multiple clinical centers, which are often in multiple countries. The aim of these studies is to demonstrate long-term efficacy and safety of the drug. Since these studies are vital in the approval of the drug, the dosage form plays a very critical role. 

Table 4-25 Detailed assessment of organic farming s impact on the...

Step 4—Perform a More Detailed Assessment of the Component... 

In situations where larger amounts, low concentration impurities or dilute feed need to be processed, a more detailed assessment and chromatography process development is advisable. Time frequently is the most stringent driver in addition to the constraints mentioned above. The purpose of the process development is to maximize throughput while maintaining acceptable robustness. Two limiting... 

It is not the intention to give a detailed assessment of how to choose the correct statistical test and apply it for a given clinical study. (For this the reader is referred to Chapter 8.) Rather, some general guidelines to the use of statistical analysis will be provided. 

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