Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Suicide depression

In depressed patients, cortical-hypothalamic-pituitary-adrenal axis hyperactivity can be explained by the hypersecretion of CRF, and secondary pituitary and adrenal gland hypertrophy. Impaired negative feedback at various CNS sites, including the hippocampus and pituitary are also likely to contribute. Downregulation of hippocampal mineralocorticoid receptors and expression is reported in depressed suicides [50]. In bipolar disorder, hyperactivity of the cortical-hypothalamic-pituitary-adrenal axis has been observed [51]. This increase in cortical-hypothalamic-pituitary-adrenal axis activity has also been observed in mixed mood states, mania and in depression in rapidcycling patients. Partial reversal of HPA overactivity is associated with treatment and recovery from depression. [Pg.893]

Rosel, P, Arranz, B., San, L. et al. Altered 5-HT2A binding sites and second messenger inositol trisphosphate (IP3) levels in hippocampus but not in frontal cortex from depressed suicide victims. Psych. Res. Neuroimag. 99 173-181,2000. [Pg.906]

Hrdina P, Faludi G, Li Q, Bendotti C, Tekes K, Sotonyi P, Palkovits M. (1998). Growth-associated protein (GAP-43), its mRNA, and protein kinase C (PKC) isoenzymes in brain regions of depressed suicides. Mol Psychiatry. 3(5) 411-8. [Pg.509]

Respiratory ejects Although preliminary studies did not reveal respiratory depressant effects at hypnotic doses of zaleplon in healthy subjects, observe caution if zaleplon is prescribed to patients with compromised respiratory function because sedatives/hypnotics have the capacity to depress respiratory drive. Depression As with other sedative/hypnotic drugs, administer zaleplon with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional overdosage is more common in this group of patients therefore, prescribe the least amount of the drug that is feasible for the patient at any one time. [Pg.1184]

Efavirenz is given orally at a dose of one 600-mg tablet per day. As an important part of the AIDS cocktail, efavirenz is administered with the same protease inhibitors and NRTIs as described in the nevirapine section. The half-hfe of efavirenz after a single dose is 52-76 h, and multiple doses lower the half-life to 40-55 h. Treatment with efavirenz has been associated with the development of serious psychiatric side-effects, including severe depression, suicidal thoughts, aggressive behavior, and paranoid and manic reactions. [Pg.90]

Cheetham SC, Crompton MR, Katona CL, Horton RW (1990) Brain 5-HTl binding sites in depressed suicides. Psychopharmacology (Berl) 102 544-548 Chen C, Rainnie DC, Greene RW, Tonegawa S (1994) Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266 291-294... [Pg.104]

Improvement of symptoms of depression or anxiety/depression, suicidal ideation, signs of toxicity (e.g., somnolence, sleep disturbances, persistent GI symptoms)... [Pg.454]

Although genetic influences on the dynamics of drug response have been studied in a wide range of disorders, most of the studies have been carried out in only the past few years. Disorders and behaviors studied include Alzheimer s disease, schizophrenia, depression, suicide, anxiety, obsessive-compulsive disorder (OCD), substance abuse, smoking, and alcoholism. Across these disorders, however, there has been a focus on only a handful of neuroeffector systems. These include apolipoprotein and the cholinergic system (in Alzhei-... [Pg.85]

Hospitalization for eating disorder depends on the weight status of the patient, the presence of medical complications, and the presence of related psychiatric comorbidities, such as depression, suicidal behavior, and OCD. Hospitalization for AN may be brief or extended. Inpatient brief hospitalization (7-14 days) is for patients who have (1) relapsed from previous treatment or have been ill for less than 6 months (2) a weight loss of 10%-15% from normal weight if they have relapsed, or 16%-20% if this is their first episode (3) hypokalemic alkalosis with serum potassium < 2.5 mEq/L and (4) cardiac arrhythmias. To promote rapid weight gain, patients can be placed on a liquid formula... [Pg.600]

Bowden CL, Huang LG, Javors MA, et al Calcium function in affective disorders and healthy controls. Biol Psychiatry 23 367-376, 1988 Bowden C, Cheetham SC, Crompton MR, et al Dopamine and its metabolites in depressed suicide victims (abstract). Can J Physiol Pharmacol 72 (suppl 1) 386,... [Pg.601]

Often there is a childhood history of hyperactivity or parental abuse or a family history of depression, suicide, or alcoholism. As with alcohol, other substances can decrease inhibition or markedly impair judgment, turning a gesture into a completed suicide. Clinicians should assume that patients with a history of substance abuse are at a higher risk for impulsive behavior that may place them or others in jeopardy. In obtaining a history, specific questions in addition to suicidal ideation or behavior should include the following ... [Pg.109]

Nevertheless, receptor studies in these areas are consistent with a role for biogenic amine function in the pathophysiology of major depression. Two of the most replicated findings are increased 5-FIT 2a receptor binding in the PFC and reduced 5-FIT receptor number and function in the brains of depressed suicide victims. These findings have led to positron emission tomography studies to quantitate the number of 5-FIT 2 and 5-FIT a receptors in the brain of patients with clinical depression (31, 32). This work has documented a 42% and a 27% reduction in 5-FIT a receptors in the raphe and mesiotemporal cortex, respectively, in unmedicated patients with primary, recurrent, familial major depression. [Pg.114]

Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, Tamminga CA, Pandey GN. Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects. J Neurochem 2001 77 916-928. [Pg.147]

Du L, Faludi G, Palkovits M, et al. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biol Psychiatry 1999 46 196-201. [Pg.97]

Baumann B, Danos P, Diekmann S, Krell D, Bielau H, Geretsegger C, Wurthmann C, Bernstein HG, Bogerts B (1999) Tyrosine hydroxylase immunorecativity in the locus coeruleus is reduced in depressed non-suicidal patients but normal in depressed suicide patients. Eur Arch Psychiatry Clin Neurosci 249 212-219... [Pg.119]

Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 2002 34 349-356. [Pg.31]


See other pages where Suicide depression is mentioned: [Pg.290]    [Pg.541]    [Pg.892]    [Pg.198]    [Pg.266]    [Pg.1181]    [Pg.1990]    [Pg.1992]    [Pg.249]    [Pg.270]    [Pg.317]    [Pg.77]    [Pg.102]    [Pg.102]    [Pg.220]    [Pg.438]    [Pg.345]    [Pg.445]    [Pg.147]    [Pg.60]    [Pg.143]    [Pg.249]    [Pg.270]    [Pg.310]    [Pg.316]    [Pg.317]    [Pg.414]    [Pg.134]    [Pg.70]    [Pg.69]    [Pg.73]    [Pg.543]   
See also in sourсe #XX -- [ Pg.173 , Pg.174 , Pg.177 ]




SEARCH



Depression suicidal

Depression suicidal

Depression suicide rates

Depression suicide risk

Major depressive disorder suicidality with

Neuroleptic-Induced Depression and Suicidality

Suicidality depression-related

Suicide

Suicide in depression

Suicide, depression and

The Production of Depression and Suicide

The Relationships Between Lipid Profile Levels, Depression, and Suicide Attempts

© 2024 chempedia.info