Receptor studies

Strange, PG (1996) Dopamine receptors studies on structure and function. Adv. Drug Res. 28 ... 

A further importance of cysteines lies in the palmitoylation of chemokine receptors. Many chemokine receptors have cysteine residues in their carboxy-terminal regions. In other GPCRs, these have been implicated in palmitoylation and in the anchoring of the carboxy-terminus to the plasma membrane. This effectively generates a fourth intracellular loop in the receptors. Studies on CCR5 have identified a three-cysteine cluster in the carboxy-terminus that is... 

Salminen, O., Whiteaker, P., Grady, S.R., Collins, A.C., McIntosh, J.M., Marks, M.J. The subunit composition and pharmacology of alpha-Conotoxin Mil-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay. Neuropharmacology. 48 696, 2005. 

Ni Q., Xu H., Partilla J. et al. Opioid peptide receptor studies. Interaction of opioid peptides and other drugs with four subtypes of the K2 receptor in guinea pig brain. Peptides. 16 1083, 1995. 

Structurally related sets of triazinoquinoline, triazinoisoquinoline and pyridotriazine derivatives have been synthesized and their binding to benzodiazepine receptors studied <06EJM445>. Pyridazino[3 ,4 3,4]pyrazolo[5,l-c]-l,2,4-triazines have been prepared and their antimicrobial activity evaluated <06PS809> <06PS2505>. 

Hofmann, K., Finn, F.M., Friesen, H.-J., Diaconescu, C., and Zahn, H. (1977) Biotinylinsulins as potential tools for receptor studies. Proc. Natl Acad. Sci. USA 74, 2697-2700. 

Pietzko, D. et al., The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone, J. Biol. Chem., 268, 4250, 1993. 

Duncan, J. S. (1999) Positron emission tomography receptor studies in epilepsy. Rev. Neurol. 155,482 188. 

By means of intracellular recording and staining methods, we have examined the responses of AL neurons to stimulation of the ipsilateral antenna with each of the sex pheromone components as well as partial and complete blends (75). In accordance with results of behavioral and sensory-receptor studies, components A and B are the most effective and potent sex pheromone components for eliciting physiological responses in the male-specific AL neurons. On the basis of these responses, we classified the neurons into two broad categories pheromone generalists and pheromone specialists (76). Pheromone generalists are neurons that respond similarly to stimulation of either the component A input channel or the component B input channel and do not respond differently when the complete, natural pheromone blend is presented to the antenna. In contrast, pheromone specialists are neurons that can discriminate between antennal stimulation with component A and stimulation with component B. There are several types of pheromone specialists. Some... 

Exhibit 2.15 shows some current assays used in ligand-receptor studies. 

Gonzalez FJ, Femandez-Salguero P (1998) The aryl hydrocarhon receptor studies using the AHR-null mice. Dmg Metab Dispos 26 1194—1198... 

Niu L, Abood LG, Hess GP (1995) Cocaine mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique. Proc Natl Acad Sci USA 92 12008-12012... 

Fig. 7. DOCK site point breakdown for the kinase receptor study. Three primary critical regions were defined (1) adenine acceptor zone, (2) adenine donor zone, (3) kinase ATP inhibitor rear hydrophobic pocket binding region. Adapted from ref. 70.

Wess, J., Nanavati, S., Vogel, Z. and Maggio, R. (1993) Functional-role of proline and tryptophan residues highly conserved among G-protein-coupled receptors studied by mutational analysis of the M3-muscarinic-receptor. EMBO Journal, 12 (1), 331-338. 

Cohen MA, Ryan PB, Spengler JD. 1991. Source-receptor study of volatile organic compounds and particulate matter in the Kanawha Valley, WV-II. Analysis of factors Contributing to VOC and particle exposure. Atmos Environ 25B 95- 107. 

Zolpidem (1) is an effective hypnotic agent indicated for the short-term treatment of insomnia. Zolpidem interacts with the GABAa receptor, and its pharmacological effect is blocked by the benzodiazepine-receptor antagonist fiumazenil (Sanger and Depoortere, 1998). Zolpidem displaces benzodiazepines more selectively from the cerebellum than the hippocampus or spinal cord, consistent with preferential interaction with the ajGABAA receptor subtype (sometimes referred to as the benzodiazepine coi receptor). Studies... 

Southeast Asian Strychrtos spp., Loganiaceae, Ang./rodenticide, animal stimulant, and ligand for glycine receptor studies... 

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