Depression activity disturbance

Amsacrine (m-AMSA) is a synthetic aminoacri-dine which intercalates into DNA and inhibits DNA topoisomerase II. m-AMSA is not cross-resistant to anthracyclines and has been particularly active in acute non-lymphocytic leukemia. Amsacrine is administred by intravenous infusion. It is metabolized in the liver and eliminated in the bile with an elimination half-life of 6-9 hours. Its major toxicity is bone marrow depression. Gastrointestinal disturbances are frequent. Neurotoxicity and cardiotoxic-ity may occur. 

Cytotoxic—inhibits growth of carcinoma of the urinary bladder, breasts, esophagus, thorax, and lungs. Increases secretion of cytokins, mainly IL-1 and TNF-a factor Protective factor against cancer Stimulates development of breast cancer Being incorporated into cellular membranes, fats modulate the activity of macrophages. They disturb proliferation of lymphocytes and depress activity of cytotoxic cells They disturb the response dependent on both B and T cells... 

Copper deficit causes decreased number of T lymphocytes and disorder in their functions it disturbs processes of antigen transformations and contributes to modulating the synthesis of cytokine IL-2, thus coordinating cell-mediated immunity causes depressed activity of antioxidative enzymes. 

McN-2880-h6 (15) suppressed experimental atrial arrhythmias preferentially in dogs733 Higher doses were required to antagonize conduction disturbances following coronary occlusion. MJ-9067 (.16) antagonizes ventricular arrhythmias in dogs and exerts membrane depressant activity in isolated Purkinje fibers.35>35... 

Depression is one of the most common psychiatric disorders. It is characterized by feeling of intense sadness, helplessness, worthlessness, and impaired functioning. Those experiencing a major depressive episode exhibit physical and psychological symptoms, such as appetite disturbances, sleep disturbances, and loss of interest in job, family, and other activities usually enjoyed. A major depressive episode is a depressed or dysphoric (extreme or exaggerated sadness, anxiety, or unhappiness) mood that interferes with daily functioning and includes five or more of the symptoms listed in Display 31-1. 

Cu deficit, excess of Mo and SO Pre-Caucasian plain, Caspian low plain, West Siberian Steppe ecosystems Meadow-Steppe, Eustric Chernozems, Solonchaks, Arenosols The reducing Cu content in the central nervous systems, depressed function of oxidation ferments and activation of catalase, demielinization of the central nervous systems, disturbance of motion, convulsions. Endemic ataxia. Lamb disease is predominant... 

Chronic use has been associated with an "amotivational syndrome" characterized by loss of interest in social activities, school, work, or other goal-directed activities. Cannabis use is cited as the cause of this phenomenon, but there is no evidence to support any causal relationship. There is evidence, however, that the symptoms of the "amotivational syndrome" are secondary to depression (Musty and Kraback 1995). In contrast to ethanol, there is no evidence to support that cannabis causes an increase in violent behavior (Murray 1986). However, cannabis use may be contraindicated in those with preexisting psychiatric disturbances such as bipolar disorder or schizophrenia. 

Loss of hair results from injury to hair follicles gastrointestinal disturbances, such as diarrhea, from inadequate replacement of enterocytes whose life span is limited to a few days nausea and vomiting from stimulation of area postrema chemoreceptors (p. 330) and lowered resistance to infection from weakening of the immune system (p. 300). In addition, cytostatics cause bone marrow depression. Resupply of blood cells depends on the mitotic activity of bone marrow stem and daughter cells. When myeloid proliferation is arrested, the short-lived granulocytes are the first to be affected (neutropenia), then blood platelets (thrombopenia) and, finally, Liillmann, Color Atlas of Pharmacology... 

Relief of symptoms of depression (except clomipramine). The activating properties of protriptyline make it particularly suitable for withdrawn and anergic patients. Agents with significant sedative action may be useful in depression associated with anxiety and sleep disturbances. The activating properties of protriptyline make it particularly suitable for withdrawn and anergic patients. 

Diphenoxylate + Atropine (Lomotil, Lonox) [C V] [Opioid Antidiarrheal] Uses D Action Constipating m CTidine congener, X GI motihty Dose Adults. Initial, 5 mg PO tid—qid until controlled, then 2.5-5 mg PO bid 20 mg/d max Peds >2 y. 0.3-0.4 mg/kg/24 h (of diphenoxylate) bid-qid, 10 mg/d max Caution [C, +] Contra Obstructive jaundice, D d/t bacterial Infxn children <2 y Disp Tabs, Liq SE Drowsiness, dizziness, xCTostomia, blurred vision, urinary retention, constipation Interactions T Effects W/ CNS depressants, opioids, EtOH, T risk HTN crisis W7 MAOIs EMS Monitor for Sxs of electrolyte disturbances and hypovolemia d/t D OD May cause Szs, hypotension, and anticholinergic effects (xerostomia [dry mouth], urine retention, flushed skin) activated charcoal may be effective for OD... 

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