Depressant activity

Other Interaction Processes. The selectivity of flotation reagents in a pulp and their functions depend on their interactions with the mineral phases to be separated, but other physicochemical and hydrodynamic processes also play roles. AH adsorption—desorption phenomena occur at the sohd—hquid interfacial region. Surface processes that influence such adsorptions include activation and depression. Activators and depressants are auxiUary reagents. 

Although benzene is not a poison such as H2S and HC1, it does depress activity by reforming and adsorption onto the catalyst. At high levels it can produce carbon. 

Select) allows the function to be picked the graph is automatically depicted together with a list of selected values. Drawing the mouse pointer slowly in a horizontal direction with the left button depressed activates an interpolation engine the coordinates are displayed on the bottom line of the list. Since the selected screen resolution (e.g., 800 x... 

Amphetamine (53) is the prototype drug in this group. One significant objective of molecular manipulation in this group is to retain the appetite depressant activity without significant central stimulation. This is as yet unrealized. Some of the drugs prepared with this purpose in mind are discussed in this section. Reductive alkylation of the nitrogen... 

It is interesting to note that some 1,5-benzodiazepines such as 29 also possess CNS depressant activity. Treatment of substituted diphenylamine 26 with methyl malonyl chloride and reduction with Raney nickel led to orthophenylenediamine analogue 27. Sodium alkoxide treatment led to lactam formation (28), and alkylation in the usual way with NaH and methyl iodide produced clobazam (29). °... 

Ethanol depresses activity in the upper brain even though it gives the illusion of being a stimulant. 

Mitragynine. Mitragynine (62) ethanedisulfonate exhibits analgesic and anti-tussive properties in animals (335). It has only weak respiratory depressant activity. 

Leuschner J, Muller J, Rudmann M. (1993). Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittelforschung. 43(6) 638-41. 

Female gender Prior history of depression Family history of depression Active substance abuse Recent stressful life event Poor social supports Previous suicide attempt Postpartum period Chronic medical illness... 

Two novel monoaminodibenzothiophenes, 9b-amino-l,4,4a,9b-tetra-hydrodibenzothiophene (113) and 9b-amino-l,2,3,4,4a,9b-hexayhydro-dibenzothiophene (114) have been synthesized from the corresponding carboxylic acid sulfones 32 and 33 by treatment with sodium methoxide and bromine followed by reduction of the resultant sulfone carbamates with LAH. A -Alkylation of both 113 and 114 gives compounds which possess CNS depressant activity. ... 

The discovery of the sedative/hynoptic activity of derivatives of barbituric acid has led to very extensive dissections of that molecule. One outcome of this work is the realization that acylurea and acylamide derivatives often exhibit CNS depressant activity. A fair number of such molecules have been prepared that contain a succinimide or glutarimide pharmacophore. For example, Michael addition of cyanide to the stereochemically xmdefined cinnamate... 

Slows intestinal motihty Dose Adul. Initial 4 mg PO, then 2 mg aftCT each loose stool, up to 16 mg/d Feds. 2—5 y, 13—20 kg 1 mg PO tid 6-8 y, 20—30 kg 2 mg PO bid 8-12 y, >30 kg 2 mg PO tid Caution [B, +] Not for acute D caused by Salmonella sp, Shigella sp, or C. difficile Contra Pseudomembranous colitis, bloody D Disp Caps, tabs, Liq SE Constipation, sedation, dizziness Interactions t Effects W/ antihistamines, CNS depressants, phenothiazines, TCAs, EtOH EMS Use caution w/ narcotics, may T risk of constipation related to opioids OD May cause constipation and CNS depression activated charcoal may be effective, naloxone (Narcan) may be effective... 

Concurrent EtOH use can T sedation contains anhydrous morphine from opium OD May cause constipation and CNS depression activated charcoal may be effective, naloxone can be used for resp depression... 

JAP77148076). Some other oxathiazoline derivatives (279) have central nervous system (CNS) activity, as tranquilizers and ataraxics with low toxicity (68SAP6804299) and some dioxazoline derivatives (280) have a modest CNS depressant activity (77JPS772). 

A series of esters of nuclear halogenated 3-carboxy-1,2,3-benzotriazin-4(3//)-ones show depressant activity, while the benzoate esters of substituted 3-(2-hydroxyethyl)-l,2,3-benzotriazin-4(3f0-one are reported to function as coronary dUating agents," as do certain other compounds of this type." 3-(o-Haloaryl)-l,2,3-benzotriazin-4(3i/> ones are claimed to have antisecretory," anoretic, anticonvulsant, and hypoglycemic activity, and a variety of other 3-aryl derivatives are stated to be relaxants, tranquilizers, sedatives, hypnotics, or cramp inhibitors. A number of derivatives of 10, R = H, in which the 3-substituent is a long alkyl chain containing a terminal sulfonamide group have been claimed to act. as antidiabetics. ... 

Nearly all central nervous system depressants have some capacity to suppress seizures by virtue of their depressant activity on the brain and spinal cord. Clonazepam and diazepam are two benzodiazepines that depress epileptiform activity and are used in the treatment of epilepsy and seizure disorders (see Chapter 32). 

A. Diazepam is metabolized in the liver by CYP3A4 and CYP2C19 efavirenz inhibits both of these isozymes and is likely to increase plasma levels of diazepam. Diazepam is almost completely converted to inactive metabolites therefore, renal elimination is not much of a concern. Lamivudine may produce fatigue as a side effect but does not potentiate the depressant activity of diazepam. Zidovudine does not induce cytochrome P450 activity, and diazepam does not have to be converted to an active form for sedative activity. 

Central nervous system (CNS) depressant activity. Ethanol (95%) extract of the seed, administered orally to mice and rats at a dose of 50 mg/kg, was inactive° . 

Cardiac depressant activity. Tincture of the gland, administered by perfusion to rabbits, produced weak activity on the... 

Cardiac depressant activity. Hot water extract of the dried rhizome, at a concentration of 3 mg/mL, was active on the guinea... 

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