Deoxyadenosine-3 -monophosphate

Adenine Deoxyadenosine Deoxyadenyiic acid Deoxyadenosine monophosphate (dAMP) Deoxyadenosine diphosphate (dADP) Deoxyadenosine triphosphate (dATP)... 

Diepoxybutane also reacts with nucleosides, nucleotides and DNA. Adducts at N of adenine were identified in incubations (pH 7) containing deoxyadenosine, deoxyadenosine monophosphate or poly(dA-dT)(dA-dT), as determined by mass spectrometry, or calf tliymus DNA as determined by a high-performance liquid chromatography/ 32P-postlabelling method (Leuratti et al., 1994). By the latter method, the authors demonstrated adduct formation to N of adenine in DNA from Chinese hamster ovary cells incubated with diepoxybutane at 37°C. 

DNA, the genetic material, is a long, unbranched polymer containing the four de-oxynucleoside monophosphates deoxyadenosine monophosphate (dAMP), de-oxythymidine monophosphate (dTMP), deoxyguanosine monophosphate (dGMP),... 

CMRL CMS CPE dAMP, dTMP Connaught Medical Research Laboratories Calgon metasilicate cytopathic effect deoxyadenosine monophosphate, deoxythymidine monophosphate, etc. 

The reducibility of adenine is not substantially influenced when it is bound in dinucleotides [80]. The half-wave potential becomes more negative in the series deoxyadenosine monophosphate (dAMP) adenine < adenosine < deoxyadenosine < adenosine monophosphate < adenosine triphosphate (ATP). The difference in E n between AMP and adenine is only 25 mV. 

Dietary purines are largely catabolized in the gut, rather than used by the body for the synthesis of nucleic acids. The end-product of purine catabolism in humans is uric add. The diet accounts f[ir less than half of the uric add appearing in the bloodstream, Most of the plasma uric add, or urate, originates from catabolism of the purines synthesized by the body (endogenous purines). The major purines are adenine and guanine. They occur mainly as nucleotides, such as adenosine triphosphate (ATP) and guanosine triphosphate (GTP), and as parts of nucleic acids. For example, the adenine in (UvfA occurs as adenosine monophosphate, and the adenine in DNA occurs as deoxyadenosine monophosphate. 

ID, one-dimensional 2D, two-dimensional 3D, three-dimensional AMP, adenosine monophosphate CNDO, complete neglect of differential overlap COSY, correlation spectroscopy CPMG, Carr-Purcell-Meiboom-Gill NMR pulse sequence CT, constant time dAMP, deoxyadenosine monophosphate DFT, density functional... 

Adefovir is a nucleotide analog of deoxyadenosine monophosphate that is active against retroviruses (like HIV), herpes viruses, and hepadnaviruses. Adefovir dipivoxil 10 mg by mouth once daily for 48 weeks has been approved for use in adult patients with chronic HBV who are either treatment naive or have lamivudine-resistant... 

Deoxyadenosine monophosphate Deoxyadenosine diphosphate Deoxyadenosine triphosphate Adenosine monophosphate Adenosine diphosphate Adenosine triphosphate... 

In order to determine the stereochemical course of the nonenzymic hydrolysis of cyclic nucleotides, and in particular to examine the role of pseudorotation, Gerlt and coworkers carried out a chiral phosphate analysis of the base-catalysed hydrolysis of cyclic deoxyadenosine monophosphate (Mehdi et al., 1983). In 0.2 m Ba(OH)2 at lOO C, cdAMP hydrolyses to a mixture of 3 dAMP and 5 dAMP. The position of label incorporation on hydrolysis in labelled water indicates P—O as opposed to C—O bond cleavage. The overall stereochemistry of hydrolysis was followed by recycliz-ing and analysing both the ring-opened products of ( O, 0) cdAMP hydrolysis (Scheme 31). 

Hereinafter, poly(X) denotes a homo-polynucleotide and X is the base symbol such as A (adenosine monophosphate), C (cytidine monophosphate), G (guanosine monophosphate), U(uridine monophosphate), I (inosine monophosphate), dA (deoxyadenosine monophosphate), etc. 

We prepared three s-SPG samples with Mw = 2100, 3800, 7200 with acid hydrolysis from a s-SPG sample (Mw = 15,000), and examined which sample can combine to poly(C) with the base number fixed at 250. Furthermore, we changed the base number in poly(dA) and fixed moleclar weight at 15,000 for s-SPG, and examined how many bases are necessary to induce the complexation. The results are presented in Fig. 4.28(a) and (b). When the number of 5 -cytidine monophosphate is large enough, the critical Mw of s-SPG for the complexation is 3000—5000. This means that, about 16—30 glucose units are necessary for the complexation. On the other hand, 25—30 of deoxyadenosine monophosphate are necessary to combine to the s-SPG with Mw= 15,000. 

In most cases the traditional abbreviations based on the term nucleoside monophosphate are used. Thus AMP stands for adenosine monophosphates (adenylate), UMP for uridine monophosphate (midylate), and NMP for any ribonucleoside monophosphate. Similarly, dAMP stands for deoxyadenosine monophosphate (deoxyadenylate), dUMP for deoxyuridine monophosphate (deoxyuridylate), and dNMP for any deoxyribonucleoside monophosphate. To illustrate certain points, the base, sugar, and phosphate group are indicated individually AMP = ARP dUMP = UdRP etc. 

Carson et al (1981) have shown that B derived lymphoblastoid cell lines have higher activity of a cytoplasmic 5 -N than T derived lines. This enzyme has a lower pH optimum as compared to ecto 5 -N and prefers deoxyadenosine monophosphate to AMP as a substrate. It is suggested that this difference in activity explains why the B cells in ADA deficient patients with severe combined immunodeficiency are partially spared from the toxic effects of high plasma deoxyadenosine levels. However, it is not yet known whether peripheral blood B and T cells have different activities of cytoplasmic 5 -N. 

VinylBhg in Cross-Metathesis Reactions. For the preparation of 5 -borono-analogues of 5 -deoxyadenosine monophosphate and 5 -thymi-dine monophosphate, the authors investigated a cross-metathesis reaction... 

Shishkin OV, Palamarchuk GV, Gorb L, Leszczynski J (2008) Opposite charges assisted extra strong C-H...O hydrogen bond in protonated 2 -deoxyadenosine monophosphate. Chem Phys Lett 452 198-205. doi 10.1016/j.cplett.2007.12.052... 

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