5 -Monophosphate cytidine

CMP Cytidine 5 -monophosphate HPLC High-performance liquid chro-... 

Fig. 4.3.2 Human sialic acid metabolism and genetic defects. -6P -6-Phosphate, -9P -9-phos-phate, CMP cytidine 5 -monophosphate, CTP cytidine 5 -triphosphate, UDP-GlcNAc uridine diphosphate-N-acetyl-D-glucosamine, ManNAc N-acetylmannosamine, NeuAc N-acetylneur-aminic acid, OGS oligosaccharides, SASD sialic acid storage disease...

The common pyrimidine ribonucleotides are cytidine 5 -monophosphate (CMP cytidylate) and uridine 5 -monophosphate (UMP uridylate), which contain the pyrimidines cytosine and uracil. De novo pyrimidine nucleotide biosynthesis (Fig. 22-36) proceeds in a somewhat different manner from purine nucleotide synthesis the six-membered pyrimidine ring is made first and then attached to ribose 5-phosphate. Required in this process is carbamoyl phosphate, also an intermediate in the urea cycle (see Fig. 18-10). However, as we noted... 

The sugar nucleotides (an uninformative name that has been used for glycosyl nucleotides, or more strictly, glycosyl esters of nucleoside di- or mono-phosphates) were discussed in this Series12 in 1973. Since then, accumulation of new data about these derivatives has continued, and now, about 35 representatives of this class are known to participate in the biosynthesis of polysaccharide chains of bacterial polymers (for a survey, see Ref. 13). These include glycosyl esters of uridine 5 -diphosphate (UDP), thymidine 5 -diphosphate (dTDP), guanosine 5 -diphosphate (GDP), cytidine 5 -diphosphate (CDP), cytidine 5 -monophosphate (CMP), and adenosine 5 -diphosphate (ADP). 

Methods have been devised166 for the separation of pseudo-contact and contact contributions to the shifts of 31P caused by [M(edta)]- (M = Pr- Y) and other complexes bonded to adenosine-5 -monophosphate and cytidine-5 -monophosphate at various pH values. 

Separation of contact and dipolar terms of isotropic P shifts has been achieved for Ln(iii) complexes of cytidine-5 -monophosphate. (397) Contact contributions to LIS in the spectra of isoquinoline and endo-norbornenol were estimated from the differences between the calculated and observed behaviour of the LSR Ln(dpm)3. (398)... 

Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5 -monophosphate (CMP)-induced structural changes... 

Pyrimidine-5 -nucleotidase effects the release of phosphate from cytidine-5 -monophosphate and uridine-5 -monophosphate and thus is an enzyme involved in the catabolism of RNA. RNA is a normal constituent of reticulocytes but not of mature RBCs. In the absence (or notable deficiency) of P-5 -N, RNA persists in RBCs and is manifested by striking basophilic stippling and mild to moderate hemolytic anemia. 

Scheme L Synthesis of a2,64inked sialyl-N-acetyllactosamine using a one-pot multi-enzyme system with in situ regeneration of CMP-Neu5Ac. Abbreviations for enzymes CSS, CMP-sialic acid synthetase NMK, nucleoside monophosphate kinase PK, pyruvate kinase PPase, pyrophosphatase. Abbreviations for compounds PEP, phosphoenolpyruvate ADP, adenosine 5 -diphosphate ATP, adenosine 5 -triphosphate CMP, cytidine 5-monophosphate CDP, cytidine 5 -diphosphate CTP, cytidine 5-triphosphate LacNAc, N-acetyllactosamine NeuSAc, N-acetylneuraminic acid PPi, inorganic pyrophosphate.

Metal-Nucleoside, -Nucleotide, and-Nucleic Acid Interactions.—The crystal structure of a cadmium derivative of cytidine 5 -monophosphate [Cd(5 -CMP)(H20)]H20 has been reported, in which cadmium is bonded to the N(3) position oh the base, to a phosphate oxygen from each of three other 5 -CMP groups and to a water molecule. In the crystal of bis-(8-azahypoxanthinato)tetra-aquocadmium(ii), the metal is six co-ordinate, two purines being co-ordinated to cadmium through N(7). ... 

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