Delivery system intelligent

Significant developments have occurred in recent years in the fields of biopolymers and biomaterials. New synthetic materials have been synthesized and tested for a variety of biomedical and related applications from linings for artifical hearts to artifical pancreas devices and from intraocular lenses to drug delivery systems. Of particular interest in the future is the development of intelligent polymers or materials with special functional groups that can be used either for specialty medical applications or as templates or scaffolds for tissue regeneration. 

Lin S, Du F, Wang Y et al (2008) An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems. Biomacromolecules 9 109-115... 

The procedure for the preparation of cross-linked chitosan microspheres coated with polysaccharide or lipid for intelligent drug delivery systems is illustrated in Fig. 11 [230]. 

The remaining elements of this chapter do not address adherence per se but the types of dose form that may be valuable in personalized medicine, from the very simple fast-dissolving tablets and buccal films to more complex electronically driven microdevices. Some delivery systems can take the patient side of variability out of the equation. It is suggested that intelligent inhalers (13) reduce the dependence of inhaled dose of the patient s inspiratory flow, for example. 

A third and complementary element of our defensive program must be good intelligence. Only through knowledge of specific threat agents, delivery systems, and national capabilities can we assure the effective development and use of our physical and medical countermeasures. 

In the last two decades, the development of poljoners which change their structures and properties in response to environmental stimuli such as pH, temperature, and light has attracted a great deal of attention (1-3). Such polymers have been called smart polymers, intelligent polymers, stimulus-sensitive pol3uners, or responsive polymers. They have been used in many applications, ranging from bioactive agent delivery to separation (4,5). Various delivery systems based on the smart polymers have been proposed because of their... 

Shiino D, Kataoka K, Koyama Y, Yokoyama M, Okano T, Sakurai Y. A self-regulated insulin delivery system using boro-nic acid gel. J Intelligent Mater Syst Struct 1994 5 311-314. 

Stimuli-responsive microcapsules are considered to be the most ideal intelligent drug delivery systems due to their relatively faster response rate and... 

Burck and Roweree suspect that the information gathered by intelligence agencies may be inherently limited. National Technical Means (NTM), which provides the bulk of their information , may monitor evidence of anti-chemical defences, exercises and delivery systems - the components of a chemical warfare capability that are the least able to be concealed from surveillance. Such evidence, insist Burck and Floweree, is not proof in itself of an offensive programme. Conversely, they contend that NTMs are much less useful in determining the purpose of research and development programmes, or the products of particular production facilities, or the secret... 

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