D-Cbl

Pai, L. M., G. Barcelo, and T. Schupbach. D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell. 103 51-61.2000. 

Roderick E. Hubbard, Structural Biology Laboratory, University of York, Heslington, York, YOlO 5DD, UK and Vernalis (R D) Ltd, Granta Park, Abington, Cambridge, CBl 6GB, UK. (rod ysbl.york.ac.uk, r.hubbard vernalis.com). 

Fang, D., et al., Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidy-linositol 3-kinase for ubiquitination... 

Zheng, N., Wang, P., Jeffrey, P. D., and Pavletich, N. P. Structure of a c-Cbl-UbcH7 complex RING domain function in ubiquitin-protein ligases. Cell 2000, 102, 533-39. 

The normal internalization of the wild-type receptor, defined as a loss of cell surface receptors (measured by decreased maximal binding or B ), was unaffected for the desensitization-deficient Thr mutant (see Fig. 6.4C,D) but may have been affected when distal carboxyl terminal residues were mutated (see Fig. 6.3). Therefore some, although not all, GPCRs show radical dissociation between desensitization and internalization. This is found not only in the dopamine Dj receptor (122) but also in the N-formyl peptide (134), the CBl cannabinoid (17), and the M2 muscarinic (155) receptors. 

The electron transitions depicted in Fig. 10 correspond to transitions of the system between states characterized by different adsorption curves. Such adsorption curves which represent the energy of the system E as function of the distance r between the particle C and the adsorbent surface for the case when particle C is a monovalent atom are schematically depicted in Fig. 11 (3, 4)- The curve I represents adsorption on an unexcited crystal, i.e., on a crystal that does not contain free electrons and holes. Curve I represents curve I shifted a distance u upwards parallel to itseff that is, it corresponds to adsorption on an excited crystal containing a free electron (in the conduction band) and a free hole (in the valence band). Curves p and n represent the adsorption curves for, respectively, strong donor, and strong acceptor chemisorption (curve n can lie either below or above curve p). The minima of curves I, n, p, I correspond to the states OL, CbL d- pL, CpL eL, CL cL -1- pL. 

Leggett JD, Aspley S, Beckett SRG, D Antona AM, Kendall DA, Kendall DA, Oleamide is a selective endogenous agonist of rat and human CBl cannabinoid receptors, Brit JPharmacol 141 253—262, 2004. 

Joazeiro, C. A., Wing, S. S., Huang, H., Leverson, J. D., Hunter, T., and Liu, Y. C. (1999). The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase, Science 286, 309-312. 

Bachmaier, K., C. Krawczyk, I. Kozieradzki, Y. Y. Kong, T. Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A. Wakeham, A. Itie, J. Le, P. S. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, and J. M. Penninger. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403 211-6.2000. 

Blake, T. J., M. Shapiro, H. C. d. Morse, and W. Y. Langdon. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif Oncogene. 6 653-657.1991. 

Bowtell, D. D., and W. Y. Langdon. The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene. 11 1561-1567.1995. 

Joazeiro, C. A., S. S. Wing, H. Huang, J. D. Leverson, T. Hunter, and Y. C. Liu. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science. 286 309-312.1999. 

Langdon, W. Y., J. W. Hartley, S. P. Klinken, S. K. Ruscetti, and H. d. Morse. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Nad Acad Sci USA. 86 1168-1172.1989a. 

Murphy, M. A., R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello, C. B. Thien, W. Y. Langdon, and D. D. Bowtell. Tissue hyperplasia arul enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol. 18 4872-4882.1998. 

Gilgun-Sherki, Y., E. Melamed, R. Mechoulam, and D. Offen. The CBl cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. Pharmacol Toxicol 2003 93(2) 66—70. Pryce, G., Z. Ahmed, D. L. Hankey, et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 2003 126(Pt. 10) 2191-2202. Mathew, R. J., W. H. Wilson, and R. Davis. Postural syncope after marijuana a transcranial Doppler study of the hemodynamics. Pharmacol Biochem Behav 2003 75(2) 309-318. 

Boynton, W.R., Matteson, L.L., Watts, J.L., Stammerjohn, S.E., Jasiniski, D.A., and Rohland, F.M. (1991) Maryland Chesapeake Bay water quality monitoring programs ecosystem processes component level 1 interpretive report No. 8. UMCEES, CBL Ref. No. 91-110. 

Depaitamento de Quimica, Universidad Autonoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Cbl. Vi-centina, Iztapalapa, C.R 09340, M co D.R, M dco... 

Bisogno T (2008) Endogenous cannabinoids structure and metabohsm. J Neuroendociinol 20 1-9 Bisogno T, Melck D, Bobrov MY, Gretskaya NM, Bezuglov VV, De Petrocellis L, Di Marzo V (2000) N-acyl-dopamines novel synthetic CBl cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimemetic activity in vitro and in vivo. Biochem J 351 817-824... 

Cbl Amine, carbuKylic add <0 Double bond, ketone, eater (d) Aromatic httie, dmdde bond, akxrfml... 

Electron paramagnetic resonance spectroscopy has proved a valuable tool in the study of AdoCbl-dependent enzymes. AdoCbl itself is EPR-silent, but upon homolysis to form Cbl(II), two spins are formed, one on the cobalt (which now has low-spin d configuration) and one on the organic radical. Typically, the two unpaired electrons remain close enough in the enzymeis active site that they interact with one another to give complex, but informative, EPR spectra. 

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