Cytokines signalling

Suppressors of cytokine signaling are a family of cytokine-inducible proteins that inhibit JAK kinases. 

O Shea, J.J., Gadina, M., and Schreiber, R.D. 2002. Cytokine signalling in 2002 new surprises in the JAK/STAT pathway. Cell 109, S121-S131. 

Taniguchi, T. 1995. Cytokine signalling through non-receptor protein tyrosine kinases. Science 268, 251-255. Takatsu, K. 1997. Cytokines involved in B cell differentiation and their sites of action. Proceedings of the Society for Experimental Biology and Medicine 215(2), 121-133. 

Yoshimura, A. 2005. Negative regulation of cytokine signalling. Clinical Reviews in Allergy and Immunology 28(3), 205-220. 

Zhang, J. G., et al.. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Nad Acad Sci USA, 1999, 96(5), 2071-6. 

Joseph J, Mudduluru G, Antony S, Vashistha S, Ajitkumar P, Somasundaram K (2004) Expression profiling of sodium butyrate (NaB)-treated cells Identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene 23 6304—6315 Kao H-Y, Lee C-H, Komarov A (2002) Isolation and characterization of mammalian HDACIO A novel histone deacetylase. J Biol Chem 277 187-193... 

Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 2008 28 112-121. 

Stumbles PA, Thomas JA, Pimm CL, Lee PT, Venaille TJ, Proksch S, Holt PG Resting respiratory tract dendritic cells preferentially stimulate T-helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Thl immunity. J Exp Med 1998 188 2019-2031. 

Tarzi M, Klunker S, Texier C, Verhoef A, Stapel SO, Akdis CA, Maillere B, Kay AB, Larche M Induction of inter-leukin-10 and suppressor of cytokine signalling-3 gene expression foUowing peptide immunotherapy. Clin Exp AUergy 2006 36 465-474. 

Rogatsky I, Ivashkiv LB. (2006) Glucocorticoid modulation of cytokine signaling. Tissue Antigens. 68, 1-12. 

Taniguchi, T. (1995). Cytokine signalling through non-receptor protein tyrosine kinases. Science 268, 251-255. 

Cytokine signals may be conducted into the nucleus at the transcription level via these central signaling pathways. As a consequence, activation takes place of transcription factors with growth regulating and morphogenetic functions. 

Cytokine signaling is strictly regulated at several sites to avoid damages resulting from uncontrolled signal transduction initiated from activated cytokine receptors. A number of cytokine signaling inhibitors have been described. 

Alexander WS, Hilton DJ. 2004. The. role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Ann Rev Immunol. 22 503-529. 

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