Respiratory tract dendritic cells

Stumbles PA, Thomas JA, Pimm CL, Lee PT, Venaille TJ, Proksch S, Holt PG Resting respiratory tract dendritic cells preferentially stimulate T-helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Thl immunity. J Exp Med 1998 188 2019-2031. 

Huh JC, Strickland DH, Jahnsen FL, Turner DJ, Thomas JA, Napoli S, Tobagus I, Stumbles PA, Sly PD, Holt PG Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 2003 198 19-30. 

Figure 32.9. Schematic representation of Type I hypersensitivity. Induction Resident respiratory tract dendritic cells (DC) take and process antigen, mature, migrate to the draining lymph nodes, and present antigen to T lymphocytes. Activated T-lymphocytes, in turn, activate B-cell differentiation into antibody-producing plasma cells. IL-4 promotes Ig isotype class switching from IgM to IgE and promotes mast cell development. IgE is associated with mast cells. Elicitation Allergen crosslinks the mast-cell-bound IgE, thereby causing the release of preformed mediators and cytokines. (See Table 32.7.) Inflammation and bronchoconstriction occur.

Macrophage and Dendritic Cell Populations in the Respiratory Tract 3... 

Holt, P.G. and Schon-Hegrad, M.A. (1987). Localization of T cells, macrophages and dendritic cells in rat respiratory tract tissue implications for immune function studies. 

Holt, P.G., Schon-Hegrad, M.A. and McMenamin, P.G. (1990a). Dendritic cells in the respiratory tract. Int. Rev. Immunol. 6, 139-149. 

McGuirk P, McCann C, Mills KH Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 2002 195 221-231. 

Nelson DJ, McMenamin C, McWilliam AS, Brenan M, Holt PG. Development of the airway epithelial dendritic cell network in the rat from class II major histocompatibility (la)-negative precursors differential regulation of la expression at different levels of the respiratory tract. J Exp Med 1994 179 203-212. 

---