Cynomolgus monkey model

Goralczyk R. Histological aspects of primate ocular toxicity with special emphasis on canthaxanthin-induced retinopathy in the cynomolgus monkey model. In Korte R, Weinbauer GF, eds. Towards New Horizons in Primate Toxicology. Muenster Waxmann, 2000 159-74. 

Ponce R, Armstrong K, Andrews K, Hensler J, Waggie K, Heffernan J, Reynolds T, Rogge M. Safety of recombinant human factor XIII in a cynomolgus monkey model of extracorporeal blood circulation. Toxicol Pathol 2005 33(6) 702-10. 

Purser, D.A. 1984. A bioassay model for testing the incapacitating effects of exposure to combustion product atmospheres using cynomolgus monkeys. Jour. Fire Sci. 2 20-36. 

Purser, D.A. 1984. A bioassay model for testing the incapacitating effects of exposure to combustion product atmospheres using cynomolgus monkeys. J. Fire Sciences 2 20-36. Purser, D.A., P.Grimshaw, and K.R.Berrill. 1984. Intoxication by cyanide in fires A study in monkeys using polyacrylonitrile. Arch. Environ. Health 39 394 100. 

Jarvis P et al (2010) The cynomolgus monkey as a model for developmental toxicity studies variability of pregnancy losses, statistical power estimates and group size considerations. Birth Defects Res B Dev Reprod Toxicol 89 175-187... 

During the out-of-season periods, reproductive hormone secretion and gonadal activity are at a complete halt. Although the basic reproductive and developmental physiology appear similar to human in the rhesus monkey and many endpoint parameters are established, the distinct reproductive seasonality requires special timing and has practical implications for widespread use of this model for DART studies. With regard to immune system evaluation it can be assumed that most of the available tests for cynomolgus monkey will also be applicable to rhesus monkeys. 

Note Parameters refer to cynomolgus monkey. Italicized parameters are also available for the marmoset model. Since marmosets lack LH, the analysis of LH bioactivity reflects CG activity/levels. 

Note In case of continued maternal dosing, milk can be collected for further analysis. Parameters refer to cynomolgus monkey. Pre-/postnatal studies are considered feasible in the marmoset model (italicized parameters should be accessible in the marmoset model). 

Note Parameters refer to cynomolgus monkey. Italicized parameters are also available for the marmoset model. Parameters for a placental transfer study in cynomolgus monkey and marmosets comprise TK/PK samples, such as maternal blood before (animal not sedated) or at (animal sedated) cesarean section, blood from umbilical cord, and collection of amnio tic fluid. 

Buse E. Development of the immune system in the cynomolgus monkey the appropriate model in human target toxicology. J Immunotoxicol 2005 2 211-6. 

---