Crosslinkable biomaterials

Sallach RE, Cui W, Wen J et al (2009) Elastin-mimetic protein polymers capable of physical and chemical crosslinking. Biomaterials 30 409 22... 

Vernon, B.L. et al, 2003. Water-borne, in situ crosslinked biomaterials from phase-segregated precursors. Journal of Biomedical Materials Research, 64A, 447—456. 

Nowatzki PJ, Tirrell DA (2004) Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking. Biomaterials 25 1261-1267... 

Bigi, A, Cojazzi G, Panzavolta S, Rubini K, Roveri, N (2001). Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials, 22,763-768. 

Allcock, H. R., Gebura, M., Kwon, S., and Neenan, T. X., Amphiphilic polyphosphazenes as membrane materials Influence of side group on radiation crosslinking, semipermeability, and surface morphology. Biomaterials. 19. 500, 1988. 

Physical crosslinked PVA cryogel is considered to have a good permeability for oxygen that is a desirable property for biomaterials [1]. 

This contribution will provide a review of polylectrolytes as biomaterials, with emphasis on recent developments. The first section will provide an overview of methods of synthesizing polyelectrolytes in the structures that are most commonly employed for biomedical applications linear polymers, crosslinked networks, and polymer grafts. In the remaining sections, the salient features of polyelectrolyte thermodynamics and the applications of polyelectrolytes for dental adhesives and restoratives, controlled release devices, polymeric drugs, prodrugs, or adjuvants, and biocompatibilizers will be discussed. These topics have been reviewed in the past, therefore previous reviews are cited and only the recent developments are considered here. 

Pieper, J. S., Oosterhof, A., Dijkstra, P. J., Veerkamp, J. H., and van Kuppevelt, T. H. (1999). Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin sulphate. Biomaterials 20, 847-858. 

These features arc used by Exfluor Research Corp. in its commercial-scale reactor to produce extraordinarily pure fluorocarbons which are specially suitable as new biomedical and biomaterials which are often orders of magnitude purer than those from other syntheses. Such reactions often produce only a single compound with virtually no hydrogen present or crosslinking occurring during the reaction. 

Singh A, Suri S, Roy K (2009) In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells. Biomaterials 30 (28) 5187-5200... 

Kim AP, Yellen P, Yun YH et al (2005) Delivery of a vector encoding mouse hyaluronan synthase 2 via a crosslinked hyaluronan film. Biomaterials 26 1585-1593... 

Quinn CP, Pathak CP, Heller A, Hubbell JA. Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors. Biomaterials 1995, 16, 389-396. 

Chien HW, Chang ZY, Tsai WB (2009) Spatial control of cellular adhesion using photo-crosslinked micropatterned polyelectrolyte multilayer films. Biomaterials 30(12) 2209-2218... 

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