Drugs Polymeric

Kanke, M., Geissler, R. G., Powell, D., Kaplan, A., and De-Luca, P. P., Interaction of microspheres with blood constituents. III. Macrophage phagocytosis of various types of polymeric drug carriers, J. Parent. Sci. Technol., 42, 157, 1988. 

Figure 6 also shows that the use of this polymeric delivery system, also known as the BIODEL polymeric drug delivery system, for BCNU greatly increases the time over which the brains of these animals are exposed to significant BCNU concentrations. The brains... 

Polyamines and their ammonium salts have been of interest because they are known to have potential applications as chelating agents (1-3), ion exchange resins (4-6), flocculants (7,8), and other industrial uses (9). Recent biomedical applications have constituted another important use of polymeric amines they have been investigated for use as biocompatable materials, polymeric drugs, immobilization of enzymes, cell-culture substratum and cancer chemotherapeutic agents (10-12). 

Polymeric drugs and drug delivery systems / Richard L. Dunn, editor, Raphael M. Ottenbrite, editor, developed from a symposium sponsored by the Division of Polymeric Chemistry, Inc. at the 200th National Meeting of the American Chemical Society, Washington, D.C., August 26-31,1990. 

Polymeric drugs—Congresses. 2. Polymeric drug delivery... 

This book is divided into four sections that cover the main topics in the field of drug delivery. The first section gives an overview of the polymers and materials currently being used in drug delivery and some of the problems with and opportunities for polymeric drug delivery. The overview chapters are followed by a section on polymeric drugs and polymer-drug... 

Polymeric drugs are macromolecules that elicit biological activity (7). Many synthetic polymers are biologically inert. However, some exhibit toxicity, while others exhibit a wide range of therapeutic activities. There are three kinds of polymer drugs polycations, polyanions, and polynucleotides. 

Probably the most promising polymeric drug carrier system involves polysaccharide molecules. These are natural polymers and are often biodegradable to products that are useful to the host or easily eliminated by the host. Dextrans have been the most extensively used polysaccharide for macromolecular prodrug preparations (79). These materials are biocompatible and the in vivo fate is directly related to their molecular weight. Moreover these macromolecules can be easily targetted to the hepatocytes with D-mannose or L-fucose (20). 

Another polysaccharide system that has received considerable interest is the chitosans which are water soluble derivatives of chitin. These materials appear to be very biocompatible and degradable and so are potentially excellent candidates as polymeric drug systems (27). 

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