Protein mimetics

Section 13.1 concludes with a consideration of some additional protein mimetic structures (Section 13.1.3). This part deals primarily with the development of a molecular tool kit that can lead to locked-in folds, bundles, and other molecular arrays (Section 13.1.3.1). An application leading to zinc finger mimetics is also presented (Section 13.1.3.1.2) J6 ... 

The main purpose of this section has been to highlight the rapid progress over recent years in studies of ligand-receptor interactions at a molecular level, and the new opportunities that arise for peptide mimetic design. This also emphasizes the need for new approaches and molecular tools in the design of conformationally defined, small molecule peptide and protein mimetics, which is the main topic of the remaining sections in this article. 

PROTEIN MIMETIC IMPRINTED GELS RESPONSIVE HYDROGELS EXHIBITING BIOMOLECULAR RECOGNITION PROPERTIES... 

Despite the ubiquitous nature of serine proteases, it is possible to design specific thrombin inhibitors by taking advantage of the accessory regulatory binding sites on the enzyme surface. The inibitors are efficacious in several experimental models of thrombosis, and above all, illustrate the feasibility of low molecular weight protein mimetics. 

Dalsin JL, Hu BH, Lee BP, Messersmith PB. Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces. J Am Chem Soc 2003 125 4253-4258. 

Metallothionein. See also http //www.bioc.uzh.ch/mtpage/MT.html http / /www.ithyroid. com / metallothionein.htm http //www.bioscience.org/knockout/mt-land2.htm http //biomaterials.bme.northwestern.edu/mussel.asp Mussel Adhesive Protein Mimetics. Website from Phillip B. 

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