In situ polymerizable and crosslinkable biomaterials

In situ polymerizable materials comprise reactive monomers and/or macromers that are injected into the tissue defect in liquid form where they cure in situ to form a solid polymer. The cured polymer or gel forms by crosslinking of reactive monomers and macromer chains to form a polymer network. Depending on the crosslinking mechanism, various classes of materials can be prepared, including photopolymerized gels, chemically crosslinked thermosets, and ion-mediated gels. Each of these types of biomaterials will be reviewed in this section. 

1 Photopolymerization using ultraviolet light-activated initiators 

Poly(propylene fumarate) (PPF) networks, which are formed by the reaction of PPF with a crosslinker and initiator, have been investigated as an injectable orthopedic biomaterial. While a number of crosslinkers, such as N-vinyl pyrrolidone (NMP) and poly(ethylene glycol) dimethacrylate, have been 

Lyme liiiscqpnale Polyexler Inal PEG nreinltfiner Calalyit 

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