Cornish studies

Clark, Cumberland. Shakespeare and science a study of Shakespeare s interest in, and literary and dramatic use of, natural phenomena with an account of the astronomy, astrology, and alchemy of his day, and his attitude towards these sciences. Birmingham Cornish Brothers, 1929. 262p. 

Historically, bladder tumors have been associated with exposures in the aniline dye industry. However, conclusive evidence for any one particular exposure could not be obtained in these studies since the workers were exposed to many chemicals within the same work area. For example, Case et al. (1954) investigated the incidence of bladder tumors among British workers in the chemical dye industry. In addition to aniline, the workers were exposed to other aromatic amines, including a- and P-naphthylamine, benzidine, and auramine. Although exposures could not be quantified, there was insufficient evidence to suggest that aniline was a cause of bladder cancers. More recent studies indicate that P-naphthylamine, 4-aminodiphenyl, 4-nitrodiphenyl, 4,4-diaminodiphenyl, or o-toluidine may be involved in increased cancers in the dye industry (Ward et al. 1991 Benya and Cornish 1994). 

Cornish, P.S. and Stewart, T.E.B. 2002. Certification - case studies with Australian market... 

Cornish, J.W. et al., A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients, Drug Alcohol Depend., 67, 177, 2002. 

McDonald B, Haszard R, Spence A, et al. 1996. A mortality study of Alzheimer s disease and aluminum exposure through inhalation of McIntyre powder in Cornish tin miners. Neurobiol Aging 17 S122-S123. 

Cornish, R. A. Bryant, C. (1975). Studies of regulatory metabolism in Moniezia expansa glutamate, and the absence of the y-aminobutyrate pathway. International Journal for Parasitology, 5 355-62. 

Gherman BF, Goldberg SD, Cornish VW, Friesner RA (2004) Mixed quantum mechanical/molecular mechanical (QM/MM) study of the deacylation reaction in a penicillin... 

Acute-duration exposure to high 1,1,1-trichloroethane concentrations failed to produce kidney lesions in rats (Adams et al. 1950 Bonnet et al. 1980 Cornish and Adefuin 1966 Krantz et al. 1959), although relative kidney weight was increased slightly at 12,000 ppm in the one study in which it was measured (Adams et al. 1950). Exposure of several animal species to moderate to high... 

Information in animals was limited to an acute-duration study in which no histopathological changes were seen in the adrenals of rats after a single 2-hour exposure to up to 15,000 ppm 1,1,1-trichloroethane (Cornish and Adefuin 1966). The NOAEL value for endocrine effects from this study is recorded in Table 2-1 and plotted in Figure 2-1. 

Limited data from animal studies (Woolverton and Balster 1981) indicate that alcohol drinkers may be more susceptible to the acute neurobehavioral effects of 1,1,1-trichloroethane. Moderate to heavy alcohol drinkers may be more susceptible to the hepatotoxicity of some chlorinated alkanes, such as carbon tetrachloride, chloroform, and 1,1,2-trichloroethane, due to ethanol induction of hepatic cytochrome P-450 isozymes involved in the activation of these compounds to intermediate hepatotoxic metabolites. Available animal studies (Cornish and Adefuin 1966 Klaassen and Plaa 1966, 1967), however, have not demonstrated that ethanol ingestion will potentiate the hepatotoxicity of 1,1,1-trichloroethane. Furthermore, evidence indicates that ethanol does not cause... 

A. Millar, P. D. Brown, J. Moore, W. A. Galloway, A. G. Cornish, T. J. Lenehan, and K. P. Lynch, Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Br J Clin Pharmacol 45 21-26 (1998). 

The control patterns of several metabolic pathways have been studied on the basis of MCA (Cornish-Bowden and C denas, 1990). Thus far, the following unorthodox themes have emerged ... 

Isotopic exchange reactions of oxygen have been studied ever since water enriched in the stable isotopes of oxygen (O18 and O17) became available in the 1930 s (Lewis and Cornish, 1933 Urey et al., 1936). 

John C. Sowden was born in Brantford, Ontario, Canada, on September 27, 1910. He was the youngest of four children of Robert and Mary Warren Sowden. The Sowden ancestry was Cornish, with some blending of Scottish and Welsh. The family had established roots in the Brantford area in the early days of Canada s history. Sowden s early schooling was obtained in the Brantford public schools and, according to family records, was chiefly remarkable for extra-curricular activities, including a high skill in English billiards. His studies apparently came so easy that no particular notice was paid them. 

Dimethyl hydrazine, unsym-Dime thy I hydrazine asym-dimethylhydrazine IV, N-dimethy[hydrazine UDMH Dimazine. C2HtN2 mol wt 60.10, C 39.97%, H 13.42%, N 46.62%. (CHj)2NNHj. Prepd industrially by the reaction of dimethylamine and chloramine by reduction of nitrosodimethylamine (obtained by treating a dimethylamine salt with sodium nitrite) Hatt, Org. Syn. coll. vol. II, 211 (1943). Subacute toxicity study Cornish, Hartung, Toxicol. Appl. Pharmacol. 15, 62 (1969). Acute toxicity data Wit-kin, Arch. Ind. Health 13, 34 (1956). Review and evaluation of studies of carcinogenicity in laboratory animals IaRC Monographs 4, 137 -143 (1974). 

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