Cornish-Bowden

Cornish-Bowden, A. and Eisenthal, R. (1978). Estimation of Michaelis constant and maximum velocity from the direct linear plot. Biochim Biophys Acta 523, 268-272. 

Copeland, R. A., and Anderson, P. S. (2001) in Textbook of Drug Design and Discovery, 3rd ed., P. Krogsgaard-Larsen, T. Liljefors, and U. Madsen, eds., Taylor and Francis, New York, pp. 328—363. Cornish-Bowden, A. (1995), Fundamentals of Enzyme Kinetics, Portland Press, London. 

Cornish-Bowden, A. (2004). The Pursuit of Perfection Aspects of Biochemical Evolution. Oxford University Press, Oxford... 

Cornish-Bowden, A. Fundamentals of Enzyme Kinetics , Portland Press London, 1995. 

A. Cornish Bowden and M. L. Cardenas, Silent genes given voice. Nature 409, 571 572... 

Storer AC, Darlison MG, Cornish-Bowden A. 1975. The nature of experimental error in enzyme kinetic measurements. Biochem J 151 361. 

Cornish-Bowden A, Koshland DE. 1975. Diagnostic uses of the Hill (logit and Nernst) plots. J Mol Biol 95 201. 

The method is not as useful with multisubstrate systems however, Cornish-Bowden and EndrenyE have presented a robust regression method to treat data with more parameters. 

A. Cornish-Bowden R. Eisenthal (1978) Biochim. Biophys. Acta 523, 268. 

For a lucid account of the kinetics of multi-enzyme systems, the reader should consult Cornish-Bowden who defines such related parameters as flux control coefficients, summation relationships, and response coefficients. 

A. Cornish-Bowden J. H. Hofmeyr (1991) Comput. Appl. Bloscl. 7, 89. 

Cornish-Bowden, A. 1999. Fundamentals of enzyme kinetics, Revised Edition. London Portland Press. 

Cornish-Bowden, A., and Cardenas, M. L., "Control on Metabolic Processes". Plenum Press, New York (1990). 

This modification is a direct linear graph that results from plotting each pair of experimental values ofi>0 and [S]. Figure E5.3 is an example of the Eisenthal and Cornish-Bowden analysis. Ku and V values are read directly from the graph. 

Eisenthal and Cornish-Bowden (direct linear) plot for an enzyme-catalyzed reaction. 

Linear mechanisms are rather common for heterogeneous catalytic reactions. Examples are given and examined by Cornish-Bowden [43] and Ker-nevez [44]. Non-linear mechanisms, i.e. those including interactions of several molecules of the same or different surface substances, however, are more frequent. For example, a widely spread step of dissociative adsorption is non-linear. 

A. Cornish-Bowden, Principles of Enzyme Kinetics, Butterworths, London, Boston, 1976 Mir, Moscow, 1979 (in Russian). 

R. A. Alberty and A. Cornish-Bowden, On the pH dependence of the apparent equilibrium constant K of a biochemical reaction, Trends Biochem. Sci. 18, 288 291 (1993). 

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