Control of Superoxide Dismutase Activity and Stability

Conformational Control of Superoxide Dismutase Activity and Stability 

From extensive studies of the structure-activity relationships, we have observed that the conformation of substituents on the macrocyclic backbone of the 

Therapeutic Aspects of Manganese(Il)-based Superoxide Dimutase Mimics 

The mechanism of ligand loss for these Mn(ii) complexes has been studied and is a second-order process, first-order in [H ] and first-order in [Mn(L)] 

The kinetic stability of the mono-trans-cyclohexano substituent SC-54417 is twice that of the unsubstituted SC-52608, and two tra s-cyclohexano groups increase the kinetic stability of the Mn complex SC-55858 to over 85 times that of the unsubstituted complex SC-52608. The increased kinetic stability of the Mn complexes by the addition of trans-cyclohexano groups is believed to be due to the greater preorganizational rigidity of the complexes. In general we observe that increasing the number of substituents increases the kinetic and thermodynamic stability of the resultant Mn(ii) complexes. 

---